Treatment of Lyme Diseasewith Human Embryonic Stem Cells: A Case Series

@article{Shroff2015TreatmentOL,
  title={Treatment of Lyme Diseasewith Human Embryonic Stem Cells: A Case Series},
  author={Geeta Shroff},
  journal={Journal of neuroinfectious diseases},
  year={2015},
  volume={2015}
}
  • G. Shroff
  • Published 3 March 2015
  • Medicine, Biology
  • Journal of neuroinfectious diseases
Background: Lyme Disease (LD) is a tick-borne disease caused by Borreliaburgdorferi (Bb) and transmitted in humans by Ixodesscapularis. LD can affect any organ of the body. The present study evaluated the efficacy and safety of human embryonic stem cell (hESC) therapy for the treatment of LD. Methods: Patients included in the present study had experienced symptoms of LD to varying degree of severities and intensities. The study consisted of treatment phases separated by gap phases in-between… 
View via Publisher
11 Citations
Background Citations
4
Methods Citations
2
Results Citations
1

Figures and Tables from this paper

11 Citations

Human Embryonic Stem Cell Therapy in Crohn’s Disease: A Case Report
  • G. Shroff
  • Medicine, Biology
    The American journal of case reports
  • 2016
TLDR
A 21-year-old male with chief complaints of intolerance to specific foods, abdominal pain, and diarrhea underwent human embryonic stem cell therapy for two months and showed symptomatic relief.
Use of Human Embryonic Stem Cells in the Treatment of Age-Related Macular Degeneration
TLDR
Although, the use of hESC therapy in a 73-yr old female with AMD showed favorable outcomes, these are not enough to confirm the efficacy of h ESC in the treatment of patients with AMD, so, future clinical trials with large number of patients assessing the efficacy and safety ofhESCs in the patients withAMD are required.
Human Embryonic Stem Cell Therapy in Chronic Spinal Cord Injury: A Retrospective Study
  • G. Shroff
  • Medicine, Biology
    Clinical and translational science
  • 2016
TLDR
HESC transplantation is safe and effective in patients with SCI and no serious adverse events (AEs) were observed.
Establishment and Use of Injectable Human Embryonic Stem Cells for Clinical Application
TLDR
The chapter shows that over 1400 patients suffering from a range of different conditions and not benefitting from traditional therapies have not had a detectable teratoma or immune reaction.
A review of the emerging potential therapy for neurological disorders: human embryonic stem cell therapy.
TLDR
It is concluded that hESC lines could be scalable and used in the treatment of various neurological disorders such as SCI, CP, and PD.
Single-photon emission tomography imaging in patients with Lyme disease treated with human embryonic stem cells
  • G. Shroff
  • Medicine, Biology
    The neuroradiology journal
  • 2018
TLDR
Single-photon emission tomography imaging could be used as a potential diagnostic tool to assess the response of Lyme disease patients to human embryonic stem cell therapy.
The Power of Stem Cells
TLDR
The science prompting the advancement of system and techniques for culturing human stem cells could prompt exceptional medicines and even cures for these and different diseases.
ESTABLISHMENT AND CHARACTERIZATION OF A NEURONAL CELL LINE DERIVED FROM A 2-CELL STAGE HUMAN EMBRYO: CLINICALLY TESTED CELL-BASED THERAPY FOR NEUROLOGICAL DISORDERS
TLDR
This is the first report of culturing and maintaining hESCs obtained from 2-celled stage without providing any culture feeder layer embryo, and these cell lines have proven to be effective for the treatment of neuronal disorders.
RESEARCH ARTICLE ESTABLISHMENT AND CHARACTERIZATION OF A NEURONAL CELL LINE DERIVED FROM A 2 -CELL STAGE HUMAN EMBRYO: CLINICALLY TESTED CELL-BASED THERAPY FOR NEUROLOGICAL DISORDERS
TLDR
This is the first report of culturing and maintaining hESCs obtained from 2-celled stage without providing any culture feeder layer embryo, and these cell lines have proven to be effective for the treatment of neuronal disorders.
Human embryonic stem cell therapy for aplastic anemia
TLDR
The study showed a remarkable improvement in the AA patient subsequent to hESC administration, and hESc therapy is safe and effective for AA patients.
...
...

References

SHOWING 1-10 OF 20 REFERENCES
Treatment of Lyme borreliosis
TLDR
If the infection is manifest, then treatment strategies should target not only the pathogen by using antibiotics but also the chronic inflammation by using anti-inflammatory drugs.
Borrelia burgdorferi infection and Lyme disease in children.
Surveillance for Lyme disease--United States, 1992-2006.
TLDR
The results presented in this report underscore the continued emergence of Lyme disease and the need for tick avoidance and early treatment interventions and can be used to target prevention campaigns to populations with increasing incidence.
The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America.
TLDR
These updated guidelines replace the previous treatment guidelines published in 2000 and list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided.
Issues in the Diagnosis and Treatment of Lyme Disease
  • S. Donta
  • Medicine, Biology
    The open neurology journal
  • 2012
TLDR
The successful treatment of Lyme disease appears to be dependent on the use of specific antibiotics over a sufficient period of time, and further treatment trials would be helpful in finding the best regimens and duration periods.
Clinical trials validate the severity of persistent Lyme disease symptoms.
  • D. Cameron
  • Medicine, Psychology
    Medical hypotheses
  • 2009
Surveillance for Lyme disease--United States, 1992-1998.
TLDR
The results presented in this report will help clinicians evaluate the prior probability of Lyme disease and provide the framework for targeting human Lyme disease vaccine use and other prevention and treatment interventions.
Point: antibiotic therapy is not the answer for patients with persisting symptoms attributable to lyme disease.
  • P. Auwaerter
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2007
TLDR
The term "chronic Lyme disease" should be discarded as misleading; rather, the term "post-Lyme disease syndrome" better reflects the postinfectious nature of this condition.
Lyme Disease: A Review
  • A. Marques
  • Medicine
    Current allergy and asthma reports
  • 2010
TLDR
The pathogenesis, epidemiology, clinical manifestations, diagnosis, treatment, and prevention of Lyme disease are reviewed.
Therapeutic potential of human embryonic stem cell transplantation in patients with cerebral palsy
TLDR
Use of hESC therapy in patients with CP is effective and safe and has demonstrated significant improvement in GMFCS-E & R scale.
...
...