Treatment of HIV-associated Kaposi's sarcoma with paclitaxel
@article{Saville1995TreatmentOH, title={Treatment of HIV-associated Kaposi's sarcoma with paclitaxel}, author={M. W. Saville and J. Lietzau and J. Pluda and W. Wilson and I. Feuerstein}, journal={The Lancet}, year={1995}, volume={346}, pages={26-28} }
We investigated whether paclitaxel was active in AIDS-associated Kaposi's sarcoma. We gave 135 mg/m2 intravenously over 3 hours every 21 days. Follow-up is available on the first 20 patients, most of whom had advanced Kaposi's sarcoma and severe immunocompromise. Neutropenia was the most frequent dose-limiting toxic effect; novel toxic effects included late fevers, rash, and eosinophilia. Creatinine increased in 2 patients and 1 patient had cardiomyopathy. There were 13 partial responses (65… CONTINUE READING
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