Treatment of HIV-associated Kaposi's sarcoma with paclitaxel

@article{Saville1995TreatmentOH,
  title={Treatment of HIV-associated Kaposi's sarcoma with paclitaxel},
  author={M. W. Saville and J. Lietzau and J. Pluda and W. Wilson and I. Feuerstein},
  journal={The Lancet},
  year={1995},
  volume={346},
  pages={26-28}
}
  • M. W. Saville, J. Lietzau, +2 authors I. Feuerstein
  • Published 1995
  • Medicine
  • The Lancet
  • We investigated whether paclitaxel was active in AIDS-associated Kaposi's sarcoma. We gave 135 mg/m2 intravenously over 3 hours every 21 days. Follow-up is available on the first 20 patients, most of whom had advanced Kaposi's sarcoma and severe immunocompromise. Neutropenia was the most frequent dose-limiting toxic effect; novel toxic effects included late fevers, rash, and eosinophilia. Creatinine increased in 2 patients and 1 patient had cardiomyopathy. There were 13 partial responses (65… CONTINUE READING
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