Treatment of HIV-associated Kaposi's sarcoma with paclitaxel.

@article{Saville1995TreatmentOH,
  title={Treatment of HIV-associated Kaposi's sarcoma with paclitaxel.},
  author={Margaret Saville and J A Lietzau and James M. Pluda and Irwin Feuerstein and Jeanne Odom and Wyndham H. Wilson and Rick Humphrey and E Feigal and Seth Steinberg and Samuel E Broder},
  journal={Lancet},
  year={1995},
  volume={346 8966},
  pages={26-8}
}
We investigated whether paclitaxel was active in AIDS-associated Kaposi's sarcoma. We gave 135 mg/m2 intravenously over 3 hours every 21 days. Follow-up is available on the first 20 patients, most of whom had advanced Kaposi's sarcoma and severe immunocompromise. Neutropenia was the most frequent dose-limiting toxic effect; novel toxic effects included late fevers, rash, and eosinophilia. Creatinine increased in 2 patients and 1 patient had cardiomyopathy. There were 13 partial responses (65… CONTINUE READING

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