Treatment of HER2-positive breast cancer: current status and future perspectives

  title={Treatment of HER2-positive breast cancer: current status and future perspectives},
  author={Carlos L. Arteaga and Mark X. Sliwkowski and Charles Osborne and Edith A. Perez and Fabio Puglisi and Luca Gianni},
  journal={Nature Reviews Clinical Oncology},
The advent of HER2-directed therapies has significantly improved the outlook for patients with HER2-positive early stage breast cancer. However, a significant proportion of these patients still relapse and die of breast cancer. Trials to define, refine and optimize the use of the two approved HER2-targeted agents (trastuzumab and lapatinib) in patients with HER2-positive early stage breast cancer are ongoing. In addition, promising new approaches are being developed including monoclonal… CONTINUE READING
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