- Jonklaas J, Talbert RL
- eds. Pharmacotherapy: A Pathophysiological…
Graves’ disease is an autoimmune syndrome where thyroid stimulating antibodies bind to and activate the thyrotropin receptor on thyroid cells resulting in hyperthyroidism (Weetman, 2000; Jonklaas, 2011). Specifically, the production of thyroid-stimulating immunoglobulin (TSI) and thyroid-stimulating hormone-binding inhibitory immunoglobulin (TBII) act on the thyroid stimulating hormone receptor to cause thyroid stimulation or thyroid inhibition, respectively.