Treatment of Gastric Ulcers with Fenugreek Seed Extract; In Vitro, In Vivo and In Silico Approaches

@article{Figer2017TreatmentOG,
  title={Treatment of Gastric Ulcers with Fenugreek Seed Extract; In Vitro, In Vivo and In Silico Approaches},
  author={Bh Figer and Raghuvir Ramakant Pissurlenkar and Premlata K. Ambre and Samidha A Kalekar and Renuka P. Munshi and M. M. Gatne and Vaishali A. Shirsat},
  journal={Indian Journal of Pharmaceutical Sciences},
  year={2017},
  volume={79},
  pages={724-730}
}
The objective of the present study was to evaluate the antiulcer or gastroprotective potential of fenugreek seed aqueous extract using in vitro and in vivo models and to elucidate the possible mechanism of fenugreek seeds by in silico analysis on H+/K+ ATPase receptor, a crucial target for mediating the gastroprotective effect. Human gastric carcinoma epithelial cell line was used as an in vitro model to study the gastro protective effect of fenugreek aqueous extract over a concentration range… Expand
6 Citations

Figures and Tables from this paper

Effect of Trigonella foenum gracecum (fenugreek) Seed Extract in Experimentally Induced Gastric Ulcer in Wistar Rats
TLDR
Fenugreek seed extract has both gastro-protective and Anti-oxidant property, and a significant decrease in ulcer index, volume of gastric juice and acidity when compared to control positive group II. Expand
Fenugreek in Health and Disease
TLDR
The addition of fenugreek in the drinking water of poultry reduces stress, and this can be an important strategy to replace the use of antibiotics such as enrofloxacin as an anti-stress agent, and thus the issues of antibiotic residues in meat, as well as widely developing antibiotic resistance, would be less. Expand
2D LC as a tool for standardization of Foenugraeci semen extracts containing compounds with anti-Helicobacter pylori activity.
TLDR
This is the first report on the bactericidal activity of vitexin, diosgenin, tigogenin and sarsasapogenin against H. pylori and the bacteriostatic activity of orientin against this bacterium. Expand
Computer aided Screening of Phytocompounds from Trigonella foenum-graecum (Fenugreek) Targeting Mutual Sub-cellular Proteins of Bacillus subtilis and Escherichia coli
Copyright: © 2020 Sibi G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in anyExpand
Helicobacter pylori eradication rate of standard triple therapy and factors affecting eradication rate at Bahir Dar city administration, Northwest Ethiopia: A prospective follow up study
TLDR
Self-reported adverse drug effects and area of residence of patients were factors affecting eradication rate significantly, indicating that modifications of the standard triple therapy observed in the different healthcare institutions are not evidence-based. Expand
Potencial gastroprotetor e cicatrizante de galactomanana extraída das sementes de Adenanthera pavonina Linn.
A doenca ulcerosa peptica (DUP) refere-se a lesoes na mucosa do estomago ou do duodeno, o principal tratamento medicamentoso indicado tem como objetivo a diminuicao da secrecao de acido gastrico eExpand

References

SHOWING 1-10 OF 26 REFERENCES
Inhibitory Effect of Aqueous Extracts of Barley and Fenugreek on Ulcer Induction in Rats
TLDR
Results revealed that animals treated with barley and fenugreek showed low lesion in stomach compared to ulcerated animals, indicating the highly potential effect of these plants against ulcer in rats. Expand
Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation.
TLDR
Investigation of the antiulcer effect of Solanum nigrum fruits extract (SNE) on cold restraint stress, gastric ulcer models and ulcer healing activity on acetic acid induced ulcer model in rats suggests that SNE was found to possess anti-ulcerogenic as well as ulcers healing properties, which might also be due to its antisecretory activity. Expand
Gastroprotective effects of flavonoids in plant extracts.
TLDR
It is concluded that plant-originated flavonoid substances are highly gastroprotective probably due to enhancement of the expression of constitutive NOS and release of NO and neuropeptides such as calcitonin gene related peptide (CGRP) released from sensory afferent nerves increasing gastric microcirculation. Expand
Study the Effect of Fenugreek Seeds on Gastric Ulcer in Experimental Rats
The aim of this study was to investigate the effect of fenugreek seeds on aspegic induced gastric mucosal ulcer in rats. Forty-eight male albino rats of Sprague Dawley strain were classified intoExpand
Gastroprotective Effect of Fenugreek Seeds (Trigonella foenum graecum) on Experimental Gastric Ulcer in Rats
TLDR
Histological studies revealed that the soluble gel fraction prevents lesion formation and is effective as ranitidine, showing that fenugreek seeds possess antiulcer potential. Expand
Evaluation of antiulcer agents with a human adenocarcinoma cell line (AGS)
TLDR
Overall results correlated well, qualitatively, with previous studies with primary cultures of rat gastric epithelial cells and rat and human studies, suggesting that the AGS cell line may also serve as a suitable model for preliminary evaluation of some antiulcer agents. Expand
The plant kingdom as a source of anti‐ulcer remedies
TLDR
Despite progress in conventional chemistry and pharmacology in producing effective drugs, the plant kingdom might provide a useful source of new anti‐ulcer compounds for development as pharmaceutical entities or as simple dietary adjuncts to existing therapies. Expand
Chemical composition and antioxidant activity of the husk and endosperm of fenugreek seeds
Abstract Fenugreek ( Trigonella foenum-graecum) is used as a spice, vegetable and a medicinal plant. In the present study, fenugreek seeds were separated into husk and endosperm. The proximateExpand
Protective effects of steroid saponins from Paris polyphylla var. yunnanensis on ethanol- or indomethacin-induced gastric mucosal lesions in rats: structural requirement for activity and mode of action.
The methanolic extract from the rhizomes of Paris polyphylla SM. var. yunnanensis (FR.) H-M. was found to potently inhibit ethanol-induced gastric lesions in rats. Through bioassay-guided separation,Expand
Effects of ethanol on gastric acid secretion and gastric mucosal cyclic AMP in the rat.
TLDR
It is concluded that the ethanol-induced decrease of cyclic AMP in the gastric mucosa is due to a decreased formation of the nucleotide, and the accompanying inhibition of the output of acid by ethanol is consistent with the view that cyclicAMP is an intracellular regulator of the Gastric acid secretion. Expand
...
1
2
3
...