Treatment of Gastric Ulcers with Fenugreek Seed Extract; In Vitro, In Vivo and In Silico Approaches

  title={Treatment of Gastric Ulcers with Fenugreek Seed Extract; In Vitro, In Vivo and In Silico Approaches},
  author={Bh Figer and Raghuvir Ramakant Pissurlenkar and Premlata K. Ambre and Samidha A Kalekar and Renuka P. Munshi and M. M. Gatne and Vaishali A. Shirsat},
  journal={Indian Journal of Pharmaceutical Sciences},
The objective of the present study was to evaluate the antiulcer or gastroprotective potential of fenugreek seed aqueous extract using in vitro and in vivo models and to elucidate the possible mechanism of fenugreek seeds by in silico analysis on H+/K+ ATPase receptor, a crucial target for mediating the gastroprotective effect. Human gastric carcinoma epithelial cell line was used as an in vitro model to study the gastro protective effect of fenugreek aqueous extract over a concentration range… Expand
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