Treatment of First Recurrence of Clostridium difficile Infection: Fidaxomicin Versus Vancomycin

@inproceedings{Cornely2012TreatmentOF,
  title={Treatment of First Recurrence of Clostridium difficile Infection: Fidaxomicin Versus Vancomycin},
  author={Oliver A Cornely and Mark A. Miller and Thomas J. Louie and Derrick W. Crook and Sherwood L. Gorbach},
  booktitle={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2012}
}
Recurrence of Clostridium difficile infection (CDI) occurs in approximately 25% of successfully treated patients. Two phase 3 randomized, double-blind trials were conducted at 154 sites in the United States, Canada, and Europe to compare fidaxomicin vs vancomycin in treating CDI. Patients with CDI received fidaxomicin 200 mg twice daily or vancomycin 125 mg 4 times daily for 10 days. The primary end point was clinical cure of CDI at end of treatment, and a secondary end point was recurrence… CONTINUE READING

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