Treatment of Eczema: Corticosteroids and Beyond

  title={Treatment of Eczema: Corticosteroids and Beyond},
  author={Melanie Chong and Luz Fonacier},
  journal={Clinical Reviews in Allergy \& Immunology},
  • M. Chong, L. Fonacier
  • Published 1 December 2016
  • Medicine, Biology
  • Clinical Reviews in Allergy & Immunology
Atopic dermatitis (AD) is a chronic inflammatory skin condition that requires a manifold approach to therapy. The goal of therapy is to restore the function of the epidermal barrier and to reduce skin inflammation. This can be achieved with skin moisturization and topical anti-inflammatory agents, such as topical corticosteroids and calcineurin inhibitors. Furthermore, proactive therapy with twice weekly use of both topical corticosteroids and calcineurin inhibitors in previously affected areas… 

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New findings and treatment options for skin diseases with barrier dysfunction regarding their efficacy, safety profile and mechanism of action are investigated, emphasizing on contact dermatitis, hand eczema and atopic dermatitis.

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Increasing Adherence with Topical Agents for Atopic Dermatitis

Methods that improve adherence include creating therapeutic plans with patient preferences in mind, early follow-up visit, increasing patient education through workshops, and discussing with patients and their caretakers their fears about treatment methods.

Not all that vesicles is herpes

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Cushing syndrome induced by long term use of corticosteroids in the management of atopic dermatitis.

A 1-month old infant who acquired iatrogenic Cushing syndrome after being applied diflucortolone valerate, a strong corticosteroid, ointment 3 to 4 times a day over the course of 4 months after being prescribed by a primary care physician.

Atopic Dermatitis Pertaining to Adolescents

This chapter will discuss management of AD in the adolescent and review specific pitfalls that may occur and the diagnosis is based on clinical history and diagnostic characteristics.

Bathing and Associated Treatments in Atopic Dermatitis

This work critically review the literature related to bathing and associated atopic dermatitis treatments, such as wet wraps, bleach baths, bath additives, and balneotherapy to provide readers with a comprehensive understanding of the impact of water and related therapies on atopy dermatitis.



Use of bleach baths for the treatment of infected atopic eczema

The historical use of bleach in medicine as well as its recent use for atopic eczema are discussed and the chemistry and safety of bleach as wellAs alternative therapies are examined.

The role of antiseptic agents in atopic dermatitis

Findings from a review of studies assessing the efficacy of antiseptics in atopic dermatitis in the last five years suggest some benefit for the inclusion of antisingptic use with the mainstay management of atopic skinitis, including a potential steroid sparring effect.

The status of corticosteroid therapy in dermatology.

On the basis of encouraging reports in the literature corticosteroid therapy may be instituted with justification for a group of unrelated, intractable and discomforting diseases such as maddening pruritus ani, sclerema neonatorum, dermatomyositis, certain cases of sarcoidosis, berylliosis, Behcet's syndrome, universal calcinosis, Reiter's disease and ulcers of sickle-cell anemia.

Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology.

The management of moderate to severe atopic dermatitis in adults with topical fluticasone propionate

Patients who entered the maintenance phase and were treated with intermittent FP for up to 16 weeks, demonstrated its superior efficacy over placebo, maintaining the improvements achieved after the initial treatment phase, reducing risk of relapse and delaying time to relapse.

Anti-CD20 (rituximab) treatment improves atopic eczema.

Emollients improve treatment results with topical corticosteroids in childhood atopic dermatitis: a randomized comparative study

Concomitant usage of emollients significantly improves xerosis and pruritus during corticosteroid treatment of atopic dermatitis and enables to maintain clinical improvement after therapy discontinuation.

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Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin condition that is associated with immune dysregulation and epidermal barrier dysfunction. The imbalance of the Th2 and Th1 pathways

Discovery of Topical Calcineurin Inhibitors and Pharmacological Profile of Pimecrolimus

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