Treatment of Cutaneous Calciphylaxis with Sodium Thiosulfate

@article{Auriemma2011TreatmentOC,
  title={Treatment of Cutaneous Calciphylaxis with Sodium Thiosulfate},
  author={M Auriemma and Angelo Carbone and Lorenzo Di Liberato and Antonietta Cupaiolo and Chiara Caponio and Clara de Simone and Antonio Tulli and Mario Bonomini and Paolo Amerio},
  journal={American Journal of Clinical Dermatology},
  year={2011},
  volume={12},
  pages={339-346}
}
Cutaneous calciphylaxis is a potentially fatal condition characterized by calcium deposition in dermal arterioles and the subsequent development of livedo reticularis, plaques, and extremely painful ulcers. This condition may be present in up to 4% of end-stage renal disease patients. Several treatments, which mainly attempt to control calcium phosphate metabolism, are available for this condition.We describe two patients treated with sodium thiosulfate with good results. Moreover, we also… 
Update on Cutaneous Calciphylaxis
  • U. Wollina
  • Medicine
    Indian journal of dermatology
  • 2013
TLDR
Multimodal therapy is warranted but only aggressive surgical debridement of cutaneous ulcers has shown significant outcome improvement.
Sodium thiosulfate in the treatment of calciphylaxis.
TLDR
Sodium thiosulfate appears to be a viable first-line treatment for calciphylaxis and should be seriously considered early in the course of treatment.
Iatrogenic Calcinosis Cutis Successfully Treated with Topical Sodium Thiosulfate
TLDR
A 6‐year‐old boy with hypoparathyroidism after thyroidectomy who was admitted to the hospital for severe hypocalcemia is treated with calcium gluconate intravenous infusion through peripheral veins, and treatment with 10% topical sodium thiosulfate is prescribed.
Sodium thiosulfate as a treatment for calciphylaxis: A case series
TLDR
Treatment of calciphylaxis remains challenging, although STS therapy, together with other treatment modalities, seems to improve disease outcome, more studies focusing on optimal dosing schemes and duration of treatment are necessary.
The calcium invasion: Calciphylaxis in Lupus.
TLDR
The case of a 52-year old woman with systemic lupus erythematosus, inappropriately treated with oral steroids for 18 years who developed renal impairment followed by skin necrosis and gangrene of right hand and died of a myocardial infarction is described.
The role of sodium thiosulphate in the treatment of calciphylaxis
TLDR
There is reason to be optimistic with regard to the efficacy of sodium thiosulphate within a multifaceted and multidisciplinary approach to treatment, but there is clearly much yet to be learned.
CMYKP The role of sodium thiosulphate in the treatment of calciphylaxis PATHOPHYSIOLOGY
TLDR
There is reason to be optimistic with regard to the efficacy of sodium thiosulphate within a multifaceted and multidisciplinary approach to treatment, but there is clearly much yet to be learned.
An Update on Calciphylaxis
TLDR
Because of the lack of consensus regarding the optimal approach to and treatment of this disorder, a high degree of clinical suspicion, early diagnosis, and multimodal and multidisciplinary treatment in collaboration with dermatology, nephrology, wound care, nutrition and pain management specialties may improve survival in patients with calciphylaxis.
Sodium thiosulfate in the treatment of non‐uremic calciphylaxis
TLDR
A case of non‐uremic calciphylaxis in a patient with normal renal and parathyroid function who had complete resolution of disease after treatment with STS is described, and STS appears to be an effective therapy for non‐UREmic calcippylaxis.
Non-uraemic calciphylaxis: a diagnostic and management challenge for the burns team
TLDR
The patient required prolonged ventilation and supportive treatment in burns critical care, combined with intensive wound management, repeated episodes of debridement, temporary wound cover using human skin allografts and reconstruction using split-thickness autograft.
...
...

References

SHOWING 1-10 OF 50 REFERENCES
Use of sodium thiosulfate in the treatment of calciphylaxis.
  • C. Musso, P. Enz, L. Algranati
  • Medicine
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
  • 2009
TLDR
A case of calciphylaxis that was cured using intravenous sodium thiosulphate treatment is reported, which is already used in the treatment of intoxication caused by cyanide, in patients with calcific nephrolithiasis and tumoral calcinosis with very good and safe results.
Successful treatment of calciphylaxis with intravenous sodium thiosulfate.
TLDR
The case of a woman receiving continuous ambulatory peritoneal dialysis who had a typical clinical presentation of calciphylaxis confirmed by x-ray and technetium scan findings is described, and treatment with intravenous sodium thiosulfate 3 times weekly was begun.
Intraperitoneal Sodium Thiosulfate for the Treatment of Calciphylaxis
TLDR
Intraperitoneal administration of sodium thiosulfate was well tolerated and led to removal of extra calcium with peritoneal dialysis and quantitated the amount ofextra calcium removed.
Successful treatment of calciphylaxis with pamidronate.
TLDR
A patient with calciphylaxis of unknown origin treated with pamidronate is reported on, indicating that bisphosphonates have been successfully applied in some patients.
Sodium Thiosulphate as a Promising Therapeutic Option to Treat Calciphylaxis
TLDR
The intravenous therapy of calciphylaxis with sodium thiosulphate might be a new effective alternative in the treatment of this life-threatening disease.
Penile Calciphylaxis: A Life-Threatening Condition Successfully Treated With Sodium Thiosulfate
TLDR
This is the first case of penile calciphylaxis whereby intravenous sodium thiosulfate was used in addition to the standard medical and surgical therapy, and the patient's wound completely healed and he has experienced no new lesions over the past 11 months.
Calciphylaxis: calcific uremic arteriolopathy and the emerging role of sodium thiosulfate
TLDR
The purpose of this report is to share with others the emerging role of sodium thiosulfate and its new application as a treatment option to be used in combination with other treatment modalities for calciphylaxis–calcific uremic arteriolopathy.
Calciphylaxis in a patient with normal renal function: response to treatment with sodium thiosulfate
TLDR
This is the first reported case of the use of sodium thiosulfate to treat calciphylaxis in a patient with normal renal function, who responded to treatment with sodium thiosisulfate.
Sodium Thiosulfate: New Hope for the Treatment of Calciphylaxis
TLDR
Intravenous sodium thiosulfate used alone or in combination with other novel emerging therapies may result in the improved clinical outcomes in this challenging clinical condition.
Rapid resolution of calciphylaxis with intravenous sodium thiosulfate and continuous venovenous haemofiltration using low calcium replacement fluid: case report.
  • G. Guerra, R. Shah, E. Ross
  • Medicine, Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2005
TLDR
A case of progressive biopsy-proven calciphylaxis that responded rapidly to a new approach to calcium removal is reported, which had an excellent outcome.
...
...