Treatment of Crohn’s Disease with Leflunomide as Second-Line Immunosuppression

  title={Treatment of Crohn’s Disease with Leflunomide as Second-Line Immunosuppression},
  author={Martin H. Holtmann and A. L. Gerts and Arndt Weinman and Peter Robert Galle and Markus Friedrich Neurath},
  journal={Digestive Diseases and Sciences},
The aim of this study was to assess the potential of leflunomide, an immunosuppressant in rheumatoid arthritis, as a second-line immunosuppression treatment of patients with Crohn's disease refractory or intolerant to azathioprine. The study cohort consisted of 24 patients. The primary end point was steroid-free remission, and secondary end points were changes in the Crohn's disease activity index (CDAI) and steroid intake, responsiveness of arthralgias and adverse events. Results were… 

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