Treatment of Codeine Dependence With Inhibitors of Cytochrome P450 2D6

  title={Treatment of Codeine Dependence With Inhibitors of Cytochrome P450 2D6},
  author={L. C. Fernandes and T. Kilicarslan and H. Kaplan and R. Tyndale and E. Sellers and M. Romach},
  journal={Journal of Clinical Psychopharmacology},
  • L. C. Fernandes, T. Kilicarslan, +3 authors M. Romach
  • Published 2002
  • Medicine
  • Journal of Clinical Psychopharmacology
  • Codeine is O-demethylated by cytochrome P450 2D6 (CYP2D6) to form the more potent drug morphine, accounting for much of codeine’s analgesic and dependence-producing properties. Because morphine production can be decreased by inhibition of CYP2D6, the authors hypothesized that CYP2D6 inhibition could be used to treat codeine dependence. A randomized, double-blind, placebo-controlled trial was conducted. All patients received brief behavioral therapy. Two weeks of baseline monitoring were… CONTINUE READING
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