Treatment of Civilian and Combat-Related Posttraumatic Stress Disorder with Topiramate

  title={Treatment of Civilian and Combat-Related Posttraumatic Stress Disorder with Topiramate},
  author={Miranda R. Andrus and Elizabeth Gilbert},
  journal={Annals of Pharmacotherapy},
  pages={1810 - 1816}
Objective: To evaluate the use of topiramate for the treatment of posttraumatic stress disorder (PTSD). Data Sources: Ovid MEDLINE (1950 to June week 4, 2010), International Pharmaceutical Abstracts (1970 to May 2010), ISI Web of Science (1945 to July 3, 2010), and Iowa Drug Information Service (searched July 6, 2010) were searched using the terms posttraumatic stress disorder and topiramate. Guidelines and other sources were identified from bibliography searches. Study Selection and Data… Expand
Treatment-refractory posttraumatic stress disorder (TRPTSD): a review and framework for the future
Clinical factors relevant to treatment-refractory PTSD; the neurobiology of extinction, as well as evidence-based psychotherapy and neuromodulation strategies for this condition are reviewed. Expand
Topiramate Treatment of Alcohol Use Disorder in Veterans with PTSD : A Randomized Controlled Pilot Trial
Background—The course of posttraumatic stress disorder (PTSD) is frequently and severely complicated by co-occurring alcohol use disorder (AUD), yet there are few reports of pharmacologic treatmentsExpand
Topiramate treatment of alcohol use disorder in veterans with posttraumatic stress disorder: a randomized controlled pilot trial.
Preliminary results indicate that in veterans with co-occurring PTSD and AUD, topiramate may be effective in reducing alcohol consumption, alcohol craving, and PTSD symptom severity-particularly hyperarousal symptoms. Expand
Identifying and managing posttraumatic stress disorder.
Primary care physicians should monitor patients with PTSD for comorbid conditions such as substance abuse, mood disorders, and suicidality, and should refer patients to behavioral health specialists and support groups when appropriate. Expand
A Review of Interventions for Treatment-Resistant Posttraumatic Stress Disorder
A traumatic experience evokes a stress response and increased anxiety in those who witness or experience the event. In most, the stress symptoms will alleviate with time. However, within aExpand
Clinician's Guide to Medications for PTSD
It is vital for the clinician to question the level of evidence supporting the medications being prescribed for PTSD, because there are a variety of influences on prescribing, including marketing, patient preferences, and clinical custom, all of which can be inconsistent with the evidence base. Expand
Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study.
A 12-week pilot study designed to test feasibility, acceptability, and preliminary efficacy of zonisamide as an adjunct to CPT for veterans with PTSD and comorbid AUD found it well-Tolerated and easily administered with CPT, which was also well-tolerated. Expand
Treatment of PTSD and Chronic Daily Headache
Treatment studies on individuals with CDH and comorbid PTSD are limited and multiple therapeutic agents or modes of interventions typically are necessary, such that comprehensive treatment simultaneously utilizes approaches with established efficacy for each individual condition. Expand
Effectiveness of topiramate in lipomatosis comorbid with agoraphobia and migraine. Case study
Although the mechanism of weight loss remains to be clarified, topiramate may be an alternative approach in patients suffering from generalized lipomatosis. Expand
PTSD Treatment for Veterans: What's Working, What's New, and What's Next.
  • M. Reisman
  • Medicine, Psychology
  • P & T : a peer-reviewed journal for formulary management
  • 2016
The author defines the disorder and discusses risk factors, treatments, and the barriers to effective care. Expand


Pharmacotherapy for post traumatic stress disorder (PTSD).
The findings of this review support the status of SSRIs as first line agents in the pharmacotherapy of PTSD, as well as their value in long-term treatment, and suggest that long term medication may be required in treating PTSD. Expand
Open-label topiramate as primary or adjunctive therapy in chronic civilian posttraumatic stress disorder: a preliminary report.
Topiramate appeared effective as add-on or monotherapy for chronic PTSD and demonstrated a rapid onset of action and minimally serious, dose-related side effects without the development of tolerance. Expand
Topiramate in Combat-Related Posttraumatic Stress Disorder
When used in addition to other empiric therapy, topiramate may be effective at reducing general symptoms of combat-related PTSD and reducing high-risk alcohol intake and nightmares. Expand
Topiramate in posttraumatic stress disorder: preliminary clinical observations.
  • J. Berlant
  • Medicine
  • The Journal of clinical psychiatry
  • 2001
The effects of the novel antiepileptic drug topiramate on 3 patients meeting DSM-IV criteria for chronic PTSD had a marked effect: reducing and even eliminating trauma-related intrusive memories and nightmares and normalizing depressed mood. Expand
Pharmacotherapy for posttraumatic stress disorder.
A systematic review of randomized controlled trials (RCTs) of the pharmacotherapy of posttraumatic stress disorder following the guidelines and using the software of the Cochrane Collaboration to provide an estimate of the effects of medication in this disorder. Expand
Efficacy and safety of topiramate monotherapy in civilian posttraumatic stress disorder: a randomized, double-blind, placebo-controlled study.
Preliminary results suggest that further, adequately powered studies of topiramate for the treatment of civilian PTSD are warranted. Expand
Antiepileptic drugs for the treatment of post-traumatic stress disorder
  • H. Berlin
  • Psychology, Medicine
  • Current psychiatry reports
  • 2007
The possibility that AEDs may be effective in the treatment of PTSD due to their antikindling effect is discussed, and suggestions for future research are made. Expand
Prospective open-label study of add-on and monotherapy topiramate in civilians with chronic nonhallucinatory posttraumatic stress disorder
The use of topiramate for treatment of chronic PTSD, at least in civilians, warrants controlled clinical trials and promising open-label findings in a new sample converge with findings of a previous study. Expand
Management of posttraumatic stress disorder: diagnostic and therapeutic issues.
Antidepressants, particularly the selective serotonin reuptake inhibitors, are the most effective form of pharmacotherapy for patients with PTSD and psychosocial techniques, such as cognitive-behavioral therapy or stress inoculation training, are effective and may be considered as adjunctive therapy with medication. Expand
Pharmacotherapy for post-traumatic stress disorder
In addition to the management of core PTSD symptoms, it is also necessary for clinicians to address important associated comorbidities, most notably, substance-use disorders and mood disturbances. Expand