Treatment of Chronic Posterior Laryngitis With Esomeprazole

  title={Treatment of Chronic Posterior Laryngitis With Esomeprazole},
  author={Michael Fredrick Vaezi and Joel E Richter and Charles Richard Stasney and Joseph R. Spiegel and Ralph A. Iannuzzi and Joseph A. Crawley and Clara Hwang and Mark Sostek and Reza Shaker},
  journal={The Laryngoscope},
Objective: To evaluate the efficacy of acid‐suppressive therapy with the proton pump inhibitor esomeprazole on the signs and symptoms of chronic posterior laryngitis (CPL) in patients with suspected reflux laryngitis. 

How Often Is GERD the Cause of Suspected Laryngopharyngeal Reflux

The standard approach to patients with laryngopharyngeal reflux is acid-suppressive therapy with proton-pump inhibitors (PPIs), however, studies suggest that these treatments may be inappropriate for some patients.

The management of suspected or confirmed laryngopharyngeal reflux patients with recalcitrant symptoms: A contemporary review

  • J. LechienV. Muls R. Sataloff
  • Medicine
    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • 2019
To summarise current knowledge about the prevalence, aetiology and management of recalcitrant laryngopharyngeal reflux (LPR) patients—those who do not respond to anti‐reflux medical treatment.

Clinical outcomes of laryngopharyngeal reflux treatment: A systematic review and meta‐analysis

To investigate the therapeutic benefit of proton pump inhibitors (PPIs) over placebo in patients with laryngopharyngeal reflux (LPR) and to analyze the epidemiological factors of heterogeneity in the

PPIs for Laryngeal Symptoms: Two More Negative Trials

Patients with unexplained laryngeal symptoms often receive proton-pump inhibitors (PPIs) for presumed laryngopharyngeAL reflux (LPR), however, PPI levels can vary greatly depending on the underlying cause.

Extra-Esophageal Reflux and Laryngeal Disease: Update From a Translational Research Team

Extraesophageal reflux (EER) has been implicated in a variety of different otorhinolaryngologic disorders including otitis media, chronic sinusitis, globus pharyngeus, laryngeal neoplasia, and many...

State of the Art: Laryngopharyngeal Reflux Treatment

This chapter will evaluate the evidence supporting the different treatment options for LPR, including lifestyle changes, medical therapies, and surgical therapies.

Chronic cough and esomeprazole: A double‐blind placebo‐controlled parallel study

Esomeprazole is a proton pump inhibitor licensed for the long‐term treatment of acid reflux in adults and the effects of esome prazole and placebo on patients with chronic cough are compared.

Diagnosis and drug treatment of extraoesophageal reflux

The authors describe the recommended management of extraoesophageal reflex, which is not only associated with heartburn and dyspepsia but can also cause a wide range of other conditions.

Laryngopharyngeal Reflux: An Update

  • Chin-Lung Kuo
  • Medicine
    Archives of Otorhinolaryngology-Head & Neck Surgery
  • 2019
The author proposes an algorithm to facilitate the assessment and management of laryngopharyngeal reflux and suggests a multidisciplinary approach to LPR diagnosis.



Empiric Esomeprazole in the Treatment of Laryngopharyngeal Reflux

Objective Objectives were to determine the efficacy of empiric treatment with esomeprazole for patients diagnosed with laryngopharyngeal reflux and to determine a treatment paradigm for this patient

Evaluation of Omeprazole in the Treatment of Reflux Laryngitis: A Prospective, Placebo‐Controlled, Randomized, Double‐Blind Study

The objective of this study was to determine the efficacy of omeprazole in treating proven reflux laryngitis.

Observations on the pathogenesis of chronic Non‐Specific pharyngitis and laryngitis

Repeated analysis of cinephotographic and cinefluorographic studies, correlated with clinical observations, have provided insight into the physiopathology of many cases of chronic non‐specific

The Reliability of the Assessment of Endoscopic Laryngeal Findings Associated With Laryngopharyngeal Reflux Disease

The reliability of the assessment of laryngoscopic findings potentially associated with lARYngopharyngeal reflux disease (LPRD) is investigated.

Intrapharyngeal Distribution of Gastric Acid Refluxate

The aims of the study were to determine intrapharyngeal distribution of gastric acid refluxate and to determine whether this distribution can better differentiate patients from control subjects compared with data obtained from a single hypopharyngeals site.

Laryngopharyngeal Reflux: Prospective Cohort Study Evaluating Optimal Dose of Proton‐Pump Inhibitor Therapy and Pretherapy Predictors of Response

An open label prospective cohort study is performed to evaluate whether twice‐daily PPI is more effective than once‐daily (QD) PPI for the treatment of LPR.

Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial

Empirical treatment with lansoprazole is efficacious in relieving symptoms of laryngeal symptoms compared to placebo and can be considered as a first-line option in managing patients with idiopathic chronic laryngitis.

Proton Pump Inhibitor Therapy for Chronic Laryngo-Pharyngitis: A Randomized Placebo-Control Trial

  • D. StewardK. Wilson J. Welge
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2004

Effect of Pantoprazole on the Course of Reflux-Associated Laryngitis: a Placebo-Controlled Double-Blind Crossover Study

The self-limited nature of reflux-associated laryngitis in non-smokers is largely underestimated and pantoprazole may be helpful especially in relieving acute symptoms, but the advantage of long-term treatment over placebo has been greatly overestimated.

Isolated head and neck symptoms due to hiatus hernia.

Symptoms of foreign-body sensation in the throat, hoarseness, neck pain, otalgia, or intractable cough were found in 22 patients with hiatus hernia and reflux. Of these, 21 had hoarseness or