Treatment of Burn and Surgical Wounds With Recombinant Human Tropoelastin Produces New Elastin Fibers in Scars

@article{Xie2017TreatmentOB,
  title={Treatment of Burn and Surgical Wounds With Recombinant Human Tropoelastin Produces New Elastin Fibers in Scars},
  author={Hua Xie and Lisa D Lucchesi and Bo Zheng and Elena R. Ladich and Teresa J Pineda and Rose Merten and Cynthia Gregory and Michael J. Rutten and Kenton Gregory},
  journal={Journal of Burn Care \& Research},
  year={2017},
  volume={38},
  pages={e859–e867}
}
Tropoelastin (TE), the soluble precursor of insoluble elastin fibers, is produced in minimal amounts in adults. Burn injuries result in inflexible collagen-rich scars because of lack of elastin fiber formation. We studied the feasibility of using recombinant human tropoelastin to enable elastin fiber production in burn and surgical scars to improve skin flexibility. In a swine hypertrophic burn scar model, normal skin and 3 × 3-cm2 partial thickness thermal burns underwent dermatome resection… 
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11 Citations
Background Citations
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11 Citations

Elastin Biomaterials in Dermal Repair.
Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring
Advancements in Regenerative Strategies Through the Continuum of Burn Care
TLDR
The aim of this review is to highlight how tissue engineering and regenerative medicine strategies are being used to address the unique challenges of burn wound healing and define the current gaps in care for both partial- and full-thickness burn injuries.
De Novo Synthesis of Elastin by Exogenous Delivery of Synthetic Modified mRNA into Skin and Elastin-Deficient Cells
The Need for Basic, Translational, and Clinical Research in the Field of Hypertrophic Scars
TLDR
This chapter will review current in vitro and in vivo modeling, and highlight research needs to address gaps in the study of HTS.
New Nanotechnologies for the Treatment and Repair of Skin Burns Infections
TLDR
This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.
A step closer to elastogenesis on demand; Inducing mature elastic fibre deposition in a natural biomaterial scaffold.
Hybrid bacterial cellulose–pectin films for delivery of bioactive molecules
TLDR
In vitro studies revealed no apparent cytotoxicity of the released compounds in mammalian CHO cells, and the antimicrobial activity of Levo released from the BC–HMP–HSA films was confirmed using Staphylococcus aureus.
MicroRNA‐21 promotes wound healing via the Smad7‐Smad2/3‐Elastin pathway
Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions
TLDR
An overview of the role of elastic fibers in musculoskeletal tissue is provided, current knowledge of the orthopedic manifestations of elastic fiber abnormalities is summarized, and opportunities for future investigation and clinical application are identified.
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