Treatment of Burn and Surgical Wounds With Recombinant Human Tropoelastin Produces New Elastin Fibers in Scars

  title={Treatment of Burn and Surgical Wounds With Recombinant Human Tropoelastin Produces New Elastin Fibers in Scars},
  author={Hua Xie and Lisa D Lucchesi and Bo Zheng and Elena R. Ladich and Teresa J Pineda and Rose Merten and Cynthia Gregory and Michael J. Rutten and Kenton Gregory},
  journal={Journal of Burn Care \& Research},
Tropoelastin (TE), the soluble precursor of insoluble elastin fibers, is produced in minimal amounts in adults. Burn injuries result in inflexible collagen-rich scars because of lack of elastin fiber formation. We studied the feasibility of using recombinant human tropoelastin to enable elastin fiber production in burn and surgical scars to improve skin flexibility. In a swine hypertrophic burn scar model, normal skin and 3 × 3-cm2 partial thickness thermal burns underwent dermatome resection… 
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The aim of this review is to highlight how tissue engineering and regenerative medicine strategies are being used to address the unique challenges of burn wound healing and define the current gaps in care for both partial- and full-thickness burn injuries.
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MicroRNA‐21 promotes wound healing via the Smad7‐Smad2/3‐Elastin pathway
Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions
An overview of the role of elastic fibers in musculoskeletal tissue is provided, current knowledge of the orthopedic manifestations of elastic fiber abnormalities is summarized, and opportunities for future investigation and clinical application are identified.


Percutaneous collagen induction therapy: an alternative treatment for burn scars.
Severe burn injuries and the role of elastin in the design of dermal substitutes.
Dermal substitutes intended to replace damaged dermal tissue in severe burn injuries have the potential to decrease wound contraction, improve scar appearance and functionality, and contribute to wound healing outcomes through a combination of elastin's mechanical and cell signaling properties.
Tropoelastin Incorporation into a Dermal Regeneration Template Promotes Wound Angiogenesis
It is shown here that by incorporating the human elastic protein tropoelastin into a dermal regeneration template (TDRT) the authors can promote angiogenesis in wound healing and have the potential to promote wound repair through enhanced vascularization.
Extracellular matrix characterization during healing of full-thickness wounds treated with a collagen/elastin dermal substitute shows improved skin regeneration in pigs.
The results suggest that the biodegradable dermal matrix served as a template for dermal tissue regeneration, allowed faster regeneration, and improved the quality of healing in large full-thickness skin defects.
Extracellular matrix molecules implicated in hypertrophic and keloid scarring
If the mechanisms of raised dermal scar formation are to be elucidated and effective therapeutic treatments developed, an integrated approach to research is required, focussing on the interactions between ECM molecules, regulatory elements and pathways.
Fibrillin‐1 and elastin are differentially expressed in hypertrophic scars and keloids
It is shown that the distribution of fibrillin‐1 and elastin is disrupted in all kinds of scars analyzed, but there are two patterns: one for normal scars and another for excessive scars.
Review of the female Duroc/Yorkshire pig model of human fibroproliferative scarring
Hypertrophic scarring after burns is an unsolved problem and remains as devastating today as it was in the 40s and it may be that the main reason for this is the lack of an accepted, useful animal
Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound.
Once thought of as neutral structural proteins, these molecules are now known to directly influence many aspects of cellular wound healing, as demonstrated by the use of acellular dermal matrices, tissue scaffolds, and wound dressings or topical products bearing ECM proteins such as collagen, hyaluronan (HA), or elastin.
Comparison between human fetal and adult skin
Most of the differences between fetal and adult skin were found at the level of dermal extracellular matrix molecules expression, suggesting that dermal components are important in fetal scarless healing.