Treatment of Burn and Surgical Wounds With Recombinant Human Tropoelastin Produces New Elastin Fibers in Scars

@article{Xie2017TreatmentOB,
  title={Treatment of Burn and Surgical Wounds With Recombinant Human Tropoelastin Produces New Elastin Fibers in Scars},
  author={H. Xie and L. Lucchesi and Bo Zheng and E. Ladich and Teresa J Pineda and R. Merten and Cynthia Gregory and M. Rutten and K. Gregory},
  journal={Journal of Burn Care \& Research},
  year={2017},
  volume={38},
  pages={e859–e867}
}
Tropoelastin (TE), the soluble precursor of insoluble elastin fibers, is produced in minimal amounts in adults. Burn injuries result in inflexible collagen-rich scars because of lack of elastin fiber formation. We studied the feasibility of using recombinant human tropoelastin to enable elastin fiber production in burn and surgical scars to improve skin flexibility. In a swine hypertrophic burn scar model, normal skin and 3 × 3-cm2 partial thickness thermal burns underwent dermatome resection… Expand
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