Treatment of Benign Prostatic Hyperplasia in Patients with Cardiovascular Disease

@article{Santillo2006TreatmentOB,
  title={Treatment of Benign Prostatic Hyperplasia in Patients with Cardiovascular Disease},
  author={Vincent M. Santillo and Franklin C. Lowe},
  journal={Drugs \& Aging},
  year={2006},
  volume={23},
  pages={795-805}
}
Pharmacological management is the most common therapeutic approach for patients with benign prostatic hyperplasia and α-adrenoceptor antagonists are the most commonly prescribed initial treatment. Although all of the α-adrenoceptor antagonists produce similar improvements in symptom scores and urinary flow rates, they have different adverse effect profiles, especially with respect to the cardiovascular system. The older α-adrenoceptor antagonists, terazosin and doxazosin, were initially… 
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References

SHOWING 1-10 OF 71 REFERENCES
Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms.
  • F. Lowe
  • Medicine
    Clinical therapeutics
  • 2004
Analysis of the functional role of ADAMTS enzymes in prostate cancer
TLDR
It can be concluded that an alpha1-AR antagonist with a low potential to interfere with blood pressure regulation and to induce cardiovascular AEs, also in patients with cardiovascular comorbidity and/or comedication, can be considered a first-choice treatment option in LUTS/BPH.
The clinical efficacy and tolerability of doxazosin standard and gastrointestinal therapeutic system for benign prostatic hyperplasia
TLDR
Both doxazosin standard and GITS are well‐tolerated, long‐term therapies that are equally effective in younger and older men, and not associated with causing sexual dysfunction.
The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia.
TLDR
Long-term combination therapy with doxazosin and finasteride was safe and reduced the risk of overall clinical progression of benign prostatic hyperplasia significantly more than did treatment with either drug alone.
Safety assessment of terazosin in the treatment of patients with symptomatic benign prostatic hyperplasia: a combined analysis.
α1-Adrenergic Receptors and Their Inhibitors in Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia
TLDR
A comprehensive overview of the role of α1-adrenergic receptors (α1ARs) as critical mediators of lower urinary tract symptoms (LUTS) and pathophysiology in benign prostatic hyperplasia (BPH) is provided, and the pharmacological antagonists of α 1ARs are reviewed.
Effects of terazosin therapy on blood pressure in men with benign prostatic hyperplasia concurrently treated with other antihypertensive medications.
Side Effects of Terazosin in the Treatment of Symptomatic Benign Prostatic Hyperplasia
  • F. Lowe
  • Medicine
    Southern medical journal
  • 1997
TLDR
It is confirmed that terazosin can be administered safely to a population of men with symptomatic benign prostatic hyperplasia with minimal clinically significant side effects.
Terazosin, doxazosin, and prazosin: current clinical experience.
The efficacy of terazosin, finasteride, or both in benign prostatic hyperplasia. Veterans Affairs Cooperative Studies Benign Prostatic Hyperplasia Study Group.
TLDR
In men with benign prostatic hyperplasia, terazosin was effective therapy, whereas finasteride was not, and the combination of terazOSin and finasterside was no more effective than terazoshin alone.
...
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