Treatment of B cell malignancies with 131I Lym-1 monoclonal antibodies.

  title={Treatment of B cell malignancies with 131I Lym-1 monoclonal antibodies.},
  author={Sally J. Denardo and Gerald L. Denardo and L F O'Grady and Edward K Hu and V M Sytsma and Stephen L. Mills and Norman B Levy and Daniel J. Macey and Chase Henderson Miller and Alan L. Epstein},
  journal={International journal of cancer. Supplement = Journal international du cancer. Supplement},
Lym-I is a murine IgG2a monoclonal antibody (MAb) that is B-cell specific but has greater avidity for malignant B cells when compared with normal B lymphocytes. It was originally produced by immunizing mice with nuclei of cultured cells from a patient with Burkitt's lymphoma. Ten patients with progressive refractory B-cell malignancies were treated with 131I-labelled Lym-I. Treatment with 131I Lym-I produced complete or partial remissions in 4 patients. Toxicity did not occur or was mild in… CONTINUE READING
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