Treatment of B-cell lymphomas with anti-idiotype antibodies alone and in combination with alpha interferon

@inproceedings{Brown1989TreatmentOB,
  title={Treatment of B-cell lymphomas with anti-idiotype antibodies alone and in combination with alpha interferon},
  author={S Brown and Richard A Miller and Sandra J. Horning and Debra K. Czerwinski and Sarah J. Hart and R. Knox McElderry and Teresa Y. Basham and Roger A. Warnke and Thomas C. Merigan and Revital Levy},
  year={1989}
}
Idiotypes are distinct clonal markers for B-cell lymphomas. Previously we reported the use of anti-idiotype antibodies in the therapy of patients with B-cell malignancies. Because synergy was demonstrated with the addition of alpha interferon to anti-idiotype antibodies in a murine lymphoma model, we performed a clinical trial combining these two agents. Here we provide an update of the original trial of anti- idiotype antibodies alone and report the outcome of the new combination trial. In 16… CONTINUE READING

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