• DOI:10.1177/0194599814555836
• Corpus ID: 9991458

Treatment of Aspirin Exacerbated Respiratory Disease with a Low Salicylate Diet

@article{Sommer2015TreatmentOA,
  title={Treatment of Aspirin Exacerbated Respiratory Disease with a Low Salicylate Diet},
  author={D. D. Sommer and Stephanie Hoffbauer and Michael Au and Leigh J. Sowerby and Michael K. Gupta and Smriti Nayan},
  journal={Otolaryngology–Head and Neck Surgery},
  year={2015},
  volume={152},
  pages={42 - 47}
}

• D. Sommer, Stephanie Hoffbauer, +3 authors S. Nayan
• Published 1 January 2015
• Medicine
• Otolaryngology–Head and Neck Surgery

Objective Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment of this condition is challenging and may include topical/systemic steroids, endoscopic sinus surgery, and/or aspirin desensitization. Study Design A prospective crossover pilot study (n = 10) was conducted in which patients were randomized into either of 2 groups with 6 weeks of regular diet (R) or 6 weeks of a low salicylate diet (LS). Setting The study was conducted in a tertiary otolaryngology clinic. Subjects Patients with AERD were enrolled in the study. Methods Subjective (Sino-nasal Outcome Test-22 [SNOT-22], Nasal Sinus Symptom Scale [NSSS], and the Asthma Control Questionnaire-7 [ACQ-7]) and objective outcome instruments (Peri-Operative Sinus Evaluation [POSE] and Lund-Kennedy Endoscopic Score [LKES]) were used to evaluate patients at baseline, 6 weeks (at crossover), and 12 weeks. Results Wilcoxon rank sum tests demonstrated that patients on the low salicylate diet had improved scores compared to their regular diet when evaluated by 4 of the 5 outcome measures (SNOT-22 pLS = 0.0059, NSSS pLS = 0.0195, LKES pLS = 0.0039, POSE pLS = 0.005). Conclusion Results of the pilot study indicate that implementation of a low salicylate diet improves the nasal symptoms and nasal endoscopy findings of individuals with AERD. Further research is required to support these findings.