Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT2a Receptor Antagonists

@article{Poyurovsky2020TreatmentOA,
  title={Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT2a Receptor Antagonists},
  author={Michael Poyurovsky and Abraham Weizman},
  journal={Drugs},
  year={2020},
  volume={80},
  pages={871 - 882}
}
Akathisia is one of the most prevalent and distressing adverse effects associated with antipsychotic drug treatment. Propranolol, a non-selective beta-adrenergic receptor antagonist, is currently considered a first-line treatment for antipsychotic-induced akathisia (AIA). Surprisingly, the evidence for its anti-akathisia effect is modest. Propranolol’s side effects (e.g. orthostatic hypotension, bradycardia), contraindications (e.g. asthma) and increased complexity in titration schedules limit… 
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8 Citations

Manage antipsychotic-induced akathisia by making changes to the antipsychotic drug regimen and/or adding anti-akathisia agents

Patients should first receive an adjustment in their antipsychotic drug regimen, and if further intervention is needed, propranolol is considered as the first-choice anti-akathisia agent.

Drug–drug interactions involving antipsychotics and antihypertensives

The current knowledge is sufficiently strong to guide clinicians in selecting safer drug combinations as summarized here to provide the clinician an insight into the pharmacokinetic and pharmacodynamic interactions between these drugs.

Akathisia and atypical antipsychotics. Relation to suicidality, agitation and depression in a clinical trial.

Akathisia is still a prevalent side effect in a clinically relevant sample of patients treated with atypical antipsychotics, and the results suggest that akath is significantly associated with depression, suicidality, and agitation in different subgroups of patients receiving antipsychotic drugs.

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The pharmacological target profile features of frequently used antipsychotic agents, in relation to estimated free plasma exposure levels at clinically efficacious dosing, are described and discussed from the rational pharmacodynamic and pharmacokinetic pros and cons point ofview.

Case of aripiprazole long‐acting‐related akathisia successfully managed with carvedilol: A case report

The author has not received research support or speakers’ honoraria from, or has served as a consultant to, Sumitomo Dainippon, Otsuka, DAIICHI SANKYO, Tsuruma, Nihon Medi-Physics and Pfizer.

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