Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT2a Receptor Antagonists
@article{Poyurovsky2020TreatmentOA, title={Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT2a Receptor Antagonists}, author={M. Poyurovsky and Abraham Weizman}, journal={Drugs}, year={2020}, volume={80}, pages={871 - 882} }
Akathisia is one of the most prevalent and distressing adverse effects associated with antipsychotic drug treatment. Propranolol, a non-selective beta-adrenergic receptor antagonist, is currently considered a first-line treatment for antipsychotic-induced akathisia (AIA). Surprisingly, the evidence for its anti-akathisia effect is modest. Propranolol’s side effects (e.g. orthostatic hypotension, bradycardia), contraindications (e.g. asthma) and increased complexity in titration schedules limit… CONTINUE READING
One Citation
References
SHOWING 1-10 OF 73 REFERENCES
Treatment of Neuroleptic-Induced Akathisia With the 5-HT2A Antagonist Trazodone
- Medicine
- Clinical neuropharmacology
- 2003
- 20
Lack of efficacy of the 5-HT3 receptor antagonist granisetron in the treatment of acute neuroleptic-induced akathisia.
- Medicine
- International clinical psychopharmacology
- 1999
- 7
Trazodone for the Treatment of Neuroleptic-Induced Acute Akathisia: A Placebo-Controlled, Double-Blind, Crossover Study
- Medicine
- Clinical neuropharmacology
- 2010
- 32
Treatment of neuroleptic induced akathisia with the 5-HT2 antagonist ritanserin.
- Medicine
- Psychopharmacology bulletin
- 1990
- 88
SSRI-Induced extrapyramidal side-effects and akathisia: implications for treatment
- Psychology, Medicine
- Journal of psychopharmacology
- 1998
- 185
The Role of Serotonin in Antipsychotic Drug Action
- Psychology, Medicine
- Neuropsychopharmacology
- 1999
- 657
- PDF
5-HT2A receptor antagonists for the treatment of neuroleptic-induced akathisia: a systematic review and meta-analysis.
- Medicine
- The international journal of neuropsychopharmacology
- 2014
- 24
- PDF
Low-Dose Mirtazapine: A New Option in the Treatment of Antipsychotic-Induced Akathisia. A Randomized, Double-Blind, Placebo- and Propranolol-Controlled Trial
- Psychology, Medicine
- Biological Psychiatry
- 2006
- 75
Serotonergic agents in the treatment of acute neuroleptic‐induced akathisia: open‐label study of buspirone and mianserin
- Medicine, Psychology
- International clinical psychopharmacology
- 1997
- 25
Treatment of neuroleptic-induced akathisia with the 5-HT2 antagonist mianserin. Double-blind, placebo-controlled study.
- Medicine, Psychology
- The British journal of psychiatry : the journal of mental science
- 1999
- 66