Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT2a Receptor Antagonists

@article{Poyurovsky2020TreatmentOA,
  title={Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT2a Receptor Antagonists},
  author={Michael Poyurovsky and Abraham Weizman},
  journal={Drugs},
  year={2020},
  volume={80},
  pages={871 - 882}
}
Akathisia is one of the most prevalent and distressing adverse effects associated with antipsychotic drug treatment. Propranolol, a non-selective beta-adrenergic receptor antagonist, is currently considered a first-line treatment for antipsychotic-induced akathisia (AIA). Surprisingly, the evidence for its anti-akathisia effect is modest. Propranolol’s side effects (e.g. orthostatic hypotension, bradycardia), contraindications (e.g. asthma) and increased complexity in titration schedules limit… Expand
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References

SHOWING 1-10 OF 83 REFERENCES
Treatment of Neuroleptic-Induced Akathisia With the 5-HT2A Antagonist Trazodone
TLDR
Trazodone is found to be a beneficial and relatively safe medication for the treatment of antipsychotic medication-induced akathisia and some improvement was noted in symptomatology of anxiety, depression, and psychosis. Expand
Lack of efficacy of the 5-HT3 receptor antagonist granisetron in the treatment of acute neuroleptic-induced akathisia.
TLDR
It seems that the 5-HT3 subtype of serotonergic receptor is not involved in the development of NIA, and 5- HT3 antagonists are ineffective in the serotonin-related pharmacotherapy of Nia. Expand
Trazodone for the Treatment of Neuroleptic-Induced Acute Akathisia: A Placebo-Controlled, Double-Blind, Crossover Study
TLDR
It is suggested that Trz's property of serotonin 2A postsynaptic receptor antagonism may be its principal mechanism for the improvement of NIA. Expand
Treatment of neuroleptic induced akathisia with the 5-HT2 antagonist ritanserin.
TLDR
First results of a single-blind trial of ritanserin in the treatment of neuroleptic-induced akathisia are encouraging and warrant further studies. Expand
SSRI-Induced extrapyramidal side-effects and akathisia: implications for treatment
  • R. Lane
  • Psychology, Medicine
  • Journal of psychopharmacology
  • 1998
TLDR
It is important that the rare occurrence of EPS in patients receiving SSRIs does not preclude their use in Parkinson's disease where their potentially significant role requires more systematic evaluation. Expand
The Role of Serotonin in Antipsychotic Drug Action
  • H. Meltzer
  • Psychology, Medicine
  • Neuropsychopharmacology
  • 1999
TLDR
Future antipsychotic drug development can include targeting multiple serotonin receptor subtypes, some, or all of which, may contribute to their differences in efficacy and side effect profile. Expand
5-HT2A receptor antagonists for the treatment of neuroleptic-induced akathisia: a systematic review and meta-analysis.
TLDR
The findings suggest that 5-HT(2A) antagonists are effective in the treatment of NIA and should be considered as a first-line treatment for neuroleptic-induced akathisia. Expand
Low-Dose Mirtazapine: A New Option in the Treatment of Antipsychotic-Induced Akathisia. A Randomized, Double-Blind, Placebo- and Propranolol-Controlled Trial
TLDR
The comparable efficacy and better tolerability of low-dose mirtazapine versus propranolol, the current first-line treatment for AIA, position mirtzapine as a favorable candidate for the treatment of acute AIA and may improve current therapeutic practices. Expand
Serotonergic agents in the treatment of acute neuroleptic‐induced akathisia: open‐label study of buspirone and mianserin
TLDR
It seems that the 5-HT1A partial agonist buspirone is of limited value in the treatment of acute neuroleptic-induced akathisia, and in contrast, it appears that low-dose mianserin is therapentically effective in acute neuroLEptic- induced akath isia. Expand
Treatment of neuroleptic-induced akathisia with the 5-HT2 antagonist mianserin. Double-blind, placebo-controlled study.
TLDR
Mianserin at a low dose may be a promising therapeutic option for patients with acute neuroleptic-induced akathisia, as well as by other relevant clinical rating scales. Expand
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