Treatment of Acute Psychosis Without Neuroleptics: Two-Year Outcomes From the Soteria Project

@article{Bola2003TreatmentOA,
  title={Treatment of Acute Psychosis Without Neuroleptics: Two-Year Outcomes From the Soteria Project},
  author={John R. Bola and Loren R. Mosher},
  journal={The Journal of Nervous and Mental Disease},
  year={2003},
  volume={191},
  pages={219-229}
}
  • J. BolaL. Mosher
  • Published 1 April 2003
  • Psychology, Medicine
  • The Journal of Nervous and Mental Disease
The Soteria project (1971–1983) compared residential treatment in the community and minimal use of antipsychotic medication with “usual” hospital treatment for patients with early episode schizophrenia spectrum psychosis. Newly diagnosed DSM-II schizophrenia subjects were assigned consecutively (1971 to 1976, N = 79) or randomly (1976 to 1979, N = 100) to the hospital or Soteria and followed for 2 years. Admission diagnoses were subsequently converted to DSM-IV schizophrenia and… 

Predicting Drug-Free Treatment Response in Acute Psychosis From the Soteria Project by

The hypothesis that an identifiable subgroup of individuals with early episode psychosis might fare better when receiving specialized psychosocial intervention and minimal or no use of antipsychotic medications is advanced.

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The use of antipsychotic medication and its association with outcomes and brain morphometry in schizophrenia : the Northern Finland Birth Cohort 1966 Study

Non-medicated subjects were more often males and in remission, less often on a disability pension, and had better clinical outcomes when compared to medicated subjects at age 34 years, and not having been hospitalized during the previous 5 years before the follow-up predicted long-term successful antipsychotic discontinuation without relapse.

A systematic review of the Soteria paradigm for the treatment of people diagnosed with schizophrenia.

It is suggested that the Soteria paradigm yields equal, and in certain specific areas, better results in the treatment of people diagnosed with first- or second-episode schizophrenia spectrum disorders when compared with conventional, medication-based approaches.

Antipsychotic medication for early episode schizophrenia.

The preliminary pattern of evidence suggests that people with early episode schizophrenia treated with typical antipsychotic medications are less likely to leave the study early than those treated with placebo, and there is very little useable data in the few studies meeting inclusion criteria.

Psychosocial Acute Treatment in Early-Episode Schizophrenia Disorders

Evidence on the treatment of early episode schizophrenia spectrum disorders that contradicts the American Psychiatric Association’s generic recommendation of antipsychotic medication treatment for at least a year is reviewed.

Is non-pharmacological treatment an option for certain schizophrenia patients?

Whether all schizophrenic people should be treated with antipsychotics for the same good prognosis is answered, and solutions for better outcomes in a greater number of patients using alternative treatment are provided.

Opinion Piece: The case for establishing a minimal medication alternative for psychosis and schizophrenia

It is recommended that healthcare providers should be encouraged to develop a psychosocial treatment package for people with psychosis or schizophrenia that provides a realistic possibility of minimising antipsychotic exposure.
...

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