Treatment of Acute Myeloid Leukemia with T Cells Expressing Chimeric Antigen Receptors Directed to C-type Lectin-like Molecule 1.

@article{Tashiro2017TreatmentOA,
  title={Treatment of Acute Myeloid Leukemia with T Cells Expressing Chimeric Antigen Receptors Directed to C-type Lectin-like Molecule 1.},
  author={Haruko Tashiro and Tim Sauer and Thomas Chung Tong Shum and Kathan S Parikh and Maksim Mamonkin and Bilal Omer and Rayne H Rouce and Premal Lulla and Cliona M Rooney and Stephen Gottschalk and Malcolm K. Brenner},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2017},
  volume={25 9},
  pages={
          2202-2213
        }
}
The successful immunotherapy of acute myeloid leukemia (AML) has been hampered because most potential antigenic targets are shared with normal hematopoietic stem cells (HSCs), increasing the risk of sustained and severe hematopoietic toxicity following treatment. C-type lectin-like molecule 1 (CLL-1) is a membrane glycoprotein expressed by >80% of AML but is absent on normal HSCs. Here we describe the development and evaluation of CLL-1-specific chimeric antigen receptor T cells (CLL-1.CAR-Ts… CONTINUE READING
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