Treatment of AIDS-related cutaneous Kaposi's sarcoma with topical alitretinoin (9-cis-retinoic acid) gel. Panretin Gel North American Study Group.

@article{Walmsley1999TreatmentOA,
  title={Treatment of AIDS-related cutaneous Kaposi's sarcoma with topical alitretinoin (9-cis-retinoic acid) gel. Panretin Gel North American Study Group.},
  author={Sharon Lynn Walmsley and Donald W. Northfelt and Barbara L. Melosky and Marcus Conant and Alvin E. Friedman-Kien and Bernd Wagner},
  journal={Journal of acquired immune deficiency syndromes},
  year={1999},
  volume={22 3},
  pages={235-46}
}
BACKGROUND Kaposi's sarcoma (KS) is the most frequent malignancy in patients with HIV. Given the promise that retinoids show in the treatment of various hyperproliferative skin disorders and in vitro evidence of inhibition of proliferation of KS cells, a randomized, controlled clinical trial was conducted. METHODS AND RESULTS A 12-week, multicenter, randomized, double-blind, vehicle-controlled safety and efficacy evaluation of topical alitretinoin 0.1% gel applied to cutaneous KS lesions was… CONTINUE READING