Treatment of ADHD in Children with Tics: A Randomized Controlled Trial

  title={Treatment of ADHD in Children with Tics: A Randomized Controlled Trial},
  author={Stephen R. Deputy},
  journal={Clinical Pediatrics},
  pages={736 - 736}
  • S. Deputy
  • Published 26 February 2002
  • Medicine, Psychology
  • Clinical Pediatrics
BackgroundThe treatment of children with attention deficit hyperactivity disorder (ADHD) and Tourette syndrome (TS) has been problematic because methylphenidate (MPH)—the most commonly used drug to treat ADHD—has been reported to worsen tics and because clonidine (CLON)—the most commonly prescribed alternative—has unproven efficacy. MethodsThe authors conducted a multicenter, randomized, double-blind clinical trial in which 136 children with ADHD and a chronic tic disorder were randomly… 
Clonidine for attention-deficit/hyperactivity disorder: I. Efficacy and tolerability outcomes.
Based on the Conners Teachers Abbreviated Symptom Questionnaire, methylphenidate offers the best combination of efficacy and tolerability for ADHD and clonidine was well tolerated despite the frequency of sedation and did offer some benefit.
Clonidine extended-release tablets for pediatric patients with attention-deficit/hyperactivity disorder.
Atomoxetine Treatment of ADHD in Children With Comorbid Tourette Syndrome
Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS.
Drug Therapy for Adults with Attention-Deficit Hyperactivity Disorder
Under controlled conditions, the aggregate literature, comprised mainly of short-term studies, shows that stimulants, norepinephrine reuptake inhibitors and specific antidepressants had clinically and statistically significant beneficial effects in the treatment of ADHD in adults.
Clonidine Extended-Release Tablets as Add-on Therapy to Psychostimulants in Children and Adolescents With ADHD
The results of this study suggest that CLON-XR in combination with stimulants is useful in reducing ADHD in children and adolescents with partial response to stimulants.
Testing tic suppression: comparing the effects of dexmethylphenidate to no medication in children and adolescents with attention-deficit/hyperactivity disorder and Tourette's disorder.
Preliminary results indicate replication of prior studies of behavioral tic suppression in youths with TD and without ADHD, and findings indicate tic reduction with acute dMPH challenge in children and adolescents with ADHD and TD.
Nonstimulants and Emerging Treatments in Adults with ADHD
Treatment of attention-deficit/hyperactivity disorder (ADHD) may positively impact the neurobiology of adult patients with ADHD and may alter the course of co-morbid disorders such as depression and substance use disorder.
Non-Stimulant Treatment of Attention-Deficit/Hyperactivity Disorder
Clinical guidelines for each of these agents, as well as their use in combination with stimulants in comorbid conditions, will be discussed.
Dopamine transporter genotype influences the physiological response to medication in ADHD.
It is found that MPH and ATX had similar effects on SICI in children with ADHD, and a genetic variation in DAT1, previously linked to ADHD risk and MPH behavioural responses, influences the neurophysiological effects of both MPH andATX.
Drug and non-drug treatments of children with ADHD and tic disorders
The preponderance of evidence suggests that stimulant medications are safe and effective in the treatment of children with ADHD and tic disorders.