Treatment of 5/6 nephrectomy rats with sulodexide: a novel therapy for chronic renal failure

  title={Treatment of 5/6 nephrectomy rats with sulodexide: a novel therapy for chronic renal failure},
  author={Ping Li and Lin-lin Ma and Ru-juan Xie and Yuan-sheng Xie and Ribao Wei and Min Yin and Jian-zhong Wang and Xiangmei Chen},
  booktitle={Acta Pharmacologica Sinica},
AbstractAim:Sulodexide, a glycosaminoglycan, could reduce albuminuria in diabetic patients. The aim of this study was to determine whether sulodexide could be used to treat chronic kidney failure in rats.Methods:Sixty Wistar rats undergone 5/6 nephrectomy, then were randomly divided into 4 groups: the model group, sulodexide group (sulodexide 5 mg/kg per day, im), irbesartan group irbesartan (20 mg/kg per day, ig) and sulodexide plus irbesartan group. Another 12 rats were enrolled into the sham… CONTINUE READING


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