Treatment issues for children with epilepsy transitioning to adult care

@article{Nabbout2017TreatmentIF,
  title={Treatment issues for children with epilepsy transitioning to adult care},
  author={Rima Nabbout and Carol S. Camfield and Danielle M. Andrade and Alexis Arzimanoglou and Catherine Chiron and Joyce A. Cramer and Jacqueline A. French and Eric Kossoff and Marco Mula and Peter R. Camfield},
  journal={Epilepsy \& Behavior},
  year={2017},
  volume={69},
  pages={153-160}
}
This is the third of three papers that summarize the second symposium on Transition in Epilepsies held in Paris in June 2016. This paper focuses on treatment issues that arise during the course of childhood epilepsy and make the process of transition to adult care more complicated. Some AEDs used during childhood, such as stiripentol, vigabatrin, and cannabidiol, are unfamiliar to adult epilepsy specialists. In addition, new drugs are being developed for treatment of specific childhood onset… 
Pharmacological Considerations When Transitioning the Care of Epilepsy Patients from Pediatric to Adult Epilepsy Centers
TLDR
The specific challenges for physicians in transition of care for epilepsy patients from a pharmacological standpoint are discussed, which include differences in metabolism and pharmacodynamics that can impact tolerability or efficacy of antiepileptic medications.
Managing Transition of Care in Adolescent Females with Epilepsy
TLDR
The value of interdisciplinary care proactively involving neurologists/epileptologists, primary care physicians, obstetricians–gynecologists, and relevant social services is illustrated and shared decision-making, effective contraceptive methods, preconceptual counseling, maintenance of bone-health, and enhanced quality of life are emphasized.
Outcome of childhood-onset epilepsy from adolescence to adulthood: Transition issues
TLDR
This paper addresses the outcome for some particularly challenging childhood-onset epileptic disorders with the goal of recommending the best approach to transition.
How can transition to adult care be best orchestrated for adolescents with epilepsy?
TLDR
The strengths and weaknesses of a variety of transition programs from around the world for adolescents with epilepsy, including those for those with normal intelligence and those with intellectual disability, are described.
Epilepsy Transition in Ambulatory Care: Experiences and Benefits of an Epilepsy Transition Team
Epilepsy is the fourth most common neurological disorder and affects people of all ages; however, at least 40% of children will continue to have seizures into adulthood. Children and youth with
Transition of Care for Adolescent and Young Adult Patients on Dietary Therapy for Epilepsy
TLDR
The rationale for establishing transition protocols for young adult patients with epilepsy and present guidelines for transition of care for patients treated with dietary therapy for epilepsy are discussed.
Improving Transitional Services for Adolescents and Young Adults with Epilepsy and Intellectual Disability
TLDR
An overview of the main themes important in care transitions for the ID-E population are provided, including precise diagnosis and management of seizures, mental health and medical comorbidities affecting care; accessing behavioral, habilitative, legal, financial, and community resources; and caretaker support.
Challenges in the Transition of Care Process for Patients with Dravet and Lennox–Gastaut Syndromes
TLDR
There is a lack of evidenced-based, family/patient-centered transition model of care for patients with DS and LGS and recommendations for an ideal transition are provided.
The evaluation and costs of transition programs for youth with epilepsy
TLDR
Transition programs in general have not been well evaluated, and very little evaluation data exist regarding transition programs for epilepsy, so more evaluative research using rigorous methodology is recommended to comprehensively assess these programs.
Epilepsy: Transition from pediatric to adult care. Recommendations of the Ontario epilepsy implementation task force
TLDR
The seven steps proposed herein may facilitate transition, thereby promoting uninterrupted and adequate care for youth with epilepsy leaving the pediatric system.
...
1
2
3
...

References

SHOWING 1-10 OF 102 REFERENCES
Pharmacology aspects during transition and at transfer in patients with epilepsy
TLDR
Optizing AED treatment at adulthood might be beneficial, even after many years of pharmacoresistance, in patients with specific pharmacoresistant epilepsy syndromes who transferred from pediatric to adult care.
Outcome of childhood-onset epilepsy from adolescence to adulthood: Transition issues
TLDR
This paper addresses the outcome for some particularly challenging childhood-onset epileptic disorders with the goal of recommending the best approach to transition.
The transition from pediatric to adult care for youth with epilepsy: Basic biological, sociological, and psychological issues
TLDR
Five basic themes that have an important effect on transition are described, leading to recommendations for how to approach adolescents and young adults during transition and some specific interventions to achieve maximum long-term adult independence and quality of life.
Transitioning pediatric patients receiving ketogenic diets for epilepsy into adulthood
TLDR
It is important for adolescents with epilepsy receiving ketogenic diets to have transition plans in place for when they become adults, and adult epilepsy diet centers are the ideal option when possible.
The pharmacological treatment of epilepsy in adults
TLDR
Antiepileptic drug choice is primarily based on evidence of efficacy and effectiveness for the individual's seizure type, but other patient-specific factors need to be considered, including age, sex, childbearing potential, comorbidities, and concomitant medications.
Combination therapy in epilepsy: when and what to use.
TLDR
Monotherapy should remain the treatment of choice for newly diagnosed epilepsy and a combination of two AEDs can be considered after failure, resulting from lack of efficacy, of one or two different monotherapy regimens.
Clobazam in the Treatment of Epilepsy: A Review of the Literature
TLDR
Clobazam appears to be a useful treatment for epilepsy as intermittent or short‐term add‐on therapy; but it should also be tried as long‐term therapy in some situations, especially as add-on therapy for patients with refractory epilepsy, as add‐ on or monotherapy for Patients with anxiety, or in some women in association with oral contraceptives.
Antiepileptic Drug‐Induced Worsening of Seizures in Children
Summary: Antiepileptic drugs (AEDs) may aggravate preexisting seizures and trigger new seizure types. However, the extent and mechanisms of this problem are unclear, for several reasons. AED trials
Rolandic epilepsy has little effect on adult life 30 years later
TLDR
The adult social outcome for children with rolandic epilepsy is remarkably better than for those with other major epilepsies and normal intelligence.
Depression and anxiety in childhood epilepsy: A review
TLDR
There is a significant need for a greater understanding of the nature of symptoms of depression and anxiety in children with epilepsy to inform treatment decisions.
...
1
2
3
4
5
...