Treatment-induced neoangiogenesis in cerebral arteriovenous malformations

  title={Treatment-induced neoangiogenesis in cerebral arteriovenous malformations},
  author={Ulrich Sure and Nick Butz and Adrian Markus Siegel and Hans Dieter Mennel and Siegfried Bien and Helmut Bertalanffy},
  journal={Clinical Neurology and Neurosurgery},
We investigated the angiogenetic and proliferative activity of the endothelium of 30 consecutive surgical cases of AVM treated at our institution by immunohistochemical detection of the PCNA, MIB-1, Flk-1 and VEGF antibodies. Endothelial positive immunostaining was observed in 87% of the cases for PCNA, in 20% for MIB-1, and in 80% for Flk-1. Of 22 individuals treated with incomplete embolization prior to surgery, 17 showed an expression of VEGF (77%), but only two of the eight patients (25… CONTINUE READING
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