Treatment failure in a case of extensively drug-resistant tuberculosis associated with selection of a GyrB mutant causing fluoroquinolone resistance

@article{Veziris2007TreatmentFI,
  title={Treatment failure in a case of extensively drug-resistant tuberculosis associated with selection of a GyrB mutant causing fluoroquinolone resistance},
  author={Nicolas Veziris and Claude Martin and Florence Brossier and François Bonnaud and François Denis and Alexandra Aubry},
  journal={European Journal of Clinical Microbiology & Infectious Diseases},
  year={2007},
  volume={26},
  pages={423-425}
}
Multidrug-resistant tuberculosis (MDR-TB), defined by resistance to both isoniazid and rifampin, is an increasing problem that accounts for 400,000 new cases worldwide each year [1]. The prognosis of individuals infected with MDR-TB remains poor, with 10–30% of cases resulting in failure and death [2]. Fluoroquinolones are some of the few potent antibiotics still active against most MDR strains of M. tuberculosis, and their use has been identified as a favorable prognostic factor in cases of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-9 of 9 references

Correlation between quinolone susceptibility patterns and sequences in the A and B Fig. 1 Initial CT scan of the patient

  • I Guillemin, V Jarlier, E Cambau
  • Eur J Clin Microbiol Infect Dis
  • 1998
2 Excerpts

Similar Papers

Loading similar papers…