Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?

@inproceedings{Joosen2010TreatmentEI,
  title={Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?},
  author={Marloes J A Joosen and August B. Smit and Herman P. M. van Helden},
  booktitle={Archives of Toxicology},
  year={2010}
}
Current treatment of organophosphate poisoning is insufficient, and survivors may suffer from long-lasting adverse effects, such as cognitive deficits and sleep-wake disturbances. In the present study, we aimed at developing a guinea pig model to investigate the benefits of immediate and delayed stand-alone therapy on the development of clinical signs, EEG… CONTINUE READING