Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study

Abstract

INTRODUCTION Cross-talk between the coagulation system and inflammatory reactions during sepsis causes organ damage followed by multiple organ dysfunction syndrome or even death. Therefore, anticoagulant therapies have been expected to be beneficial in the treatment of severe sepsis. Recombinant human soluble thrombomodulin (rhTM) binds to thrombin to… (More)
DOI: 10.1186/cc10228

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