Treatment effect on brain atrophy correlates with treatment effect on disability in multiple sclerosis

@article{Sormani2014TreatmentEO,
  title={Treatment effect on brain atrophy correlates with treatment effect on disability in multiple sclerosis},
  author={M. Sormani and D. Arnold and N. De Stefano},
  journal={Annals of Neurology},
  year={2014},
  volume={75}
}
  • M. Sormani, D. Arnold, N. De Stefano
  • Published 2014
  • Medicine
  • Annals of Neurology
  • OBJECTIVE To evaluate the extent to which treatment effect on brain atrophy is able to mediate, at the trial level, the treatment effect on disability progression in relapsing-remitting multiple sclerosis (RRMS). [...] Key MethodMETHODS We collected all published randomized clinical trials in RRMS lasting at least 2 years and including as endpoints disability progression (defined as 6 or 3 months confirmed 1-point increase on the Expanded Disability Status Scale), active magnetic resonance imaging (MRI…Expand Abstract
    202 Citations

    Paper Mentions

    Interventional Clinical Trial
    STUDY OBJECTIVES: Primary Objective: Assessment of treatment safety based on incidence of any treatment emergent/treatment associated adverse events prior to discharge and at 1, 3… Expand
    ConditionsMultiple Sclerosis, Relapsing-Remitting
    InterventionBiological, Other
    Interventional Clinical Trial
    STUDY OBJECTIVES: Primary Objective: Assessment of treatment safety based on incidence of any treatment emergent/treatment associated adverse events prior to discharge and at 1, 3… Expand
    ConditionsMultiple Sclerosis, Relapsing-Remitting
    InterventionBiological, Other
    Interventional Clinical Trial
    STUDY OBJECTIVES: Primary Objective: Assessment of treatment safety based on incidence of any treatment emergent/treatment associated adverse events prior to discharge and at 1, 3… Expand
    ConditionsMultiple Sclerosis, Relapsing-Remitting
    InterventionBiological, Other
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