Treatment concepts of acute promyelocytic leukemia

  title={Treatment concepts of acute promyelocytic leukemia},
  author={Eva Lengfelder and Susanne Saussele and Andreas Weisser and Thomas B{\"u}chner and R{\"u}diger Hehlmann},
  journal={Critical reviews in oncology/hematology},
  volume={56 2},
In the past, acute promyelocytic leukemia (APL) was associated with a high risk of early mortality resulting from severe coagulopathy, frequently inducing fatal cerebral hemorrhage. With the introduction of the differentiating agent all-trans retinioc acid (ATRA) APL has changed to the best curable subtype of acute myeloid leukemia (AML). With ATRA and chemotherapy approximately 70-80% of patients with newly diagnosed APL achieve long-term remission and are probably cured. PML/RARalpha, the… CONTINUE READING
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