Treatment and prevention of urinary tract infection with orally active FimH inhibitors.

@article{Cusumano2011TreatmentAP,
  title={Treatment and prevention of urinary tract infection with orally active FimH inhibitors.},
  author={Corinne K Cusumano and Jerome S Pinkner and Zhenfu Han and Sarah E. Greene and Bradley A Ford and Jan R. Crowley and Jeffrey P. Henderson and James W Janetka and Scott J Hultgren},
  journal={Science translational medicine},
  year={2011},
  volume={3 109},
  pages={109ra115}
}
Chronic and recurrent urinary tract infections pose a serious medical problem because there are few effective treatment options. Patients with chronic urinary tract infections are commonly treated with long-term prophylactic antibiotics that promote the development of antibiotic-resistant forms of uropathogenic Escherichia coli (UPEC), further complicating treatment. We developed small-molecular weight compounds termed mannosides that specifically inhibit the FimH type 1 pilus lectin of UPEC… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

A randomized double-blind noninferiority trial in premenopausal women

  • M. A. Beerepoot, G. ter Riet, +9 authors Cranberries vs antibiotics to prevent urinary tract infections
  • Arch. Intern. Med. 171, 1270–1278
  • 2011
1 Excerpt

Risk factors for fluoroquinolone-resistant Escherichia coli in adults with community-onset febrile urinary tract infection

  • W. E. van der Starre, C. van Nieuwkoop, +10 authors J. T. van Dissel
  • J. Antimicrob. Chemother
  • 2011
1 Excerpt

A global perspective

  • J. Ho, P. A. Tambyah, D. L. Paterson, Multiresistant Gram-negative infections
  • Curr. Opin. Infect. Dis. 23, 546–553
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…