Treatment and prevention of urinary tract infection with orally active FimH inhibitors.

  title={Treatment and prevention of urinary tract infection with orally active FimH inhibitors.},
  author={Corinne K Cusumano and Jerome S Pinkner and Zhenfu Han and Sarah E. Greene and Bradley A Ford and Jan R. Crowley and Jeffrey P. Henderson and James W Janetka and Scott J Hultgren},
  journal={Science translational medicine},
  volume={3 109},
Chronic and recurrent urinary tract infections pose a serious medical problem because there are few effective treatment options. Patients with chronic urinary tract infections are commonly treated with long-term prophylactic antibiotics that promote the development of antibiotic-resistant forms of uropathogenic Escherichia coli (UPEC), further complicating treatment. We developed small-molecular weight compounds termed mannosides that specifically inhibit the FimH type 1 pilus lectin of UPEC… CONTINUE READING
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