Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA.

@article{Trojan1993TreatmentAP,
  title={Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA.},
  author={J Trojan and Thomas R. Johnson and Susan D. Rudin and Mark L. Tykocinski and Joseph Ilan},
  journal={Science},
  year={1993},
  volume={259 5091},
  pages={94-7}
}
Rat C6 glioma cells express insulin-like growth factor I (IGF-I) and form rapidly growing tumors in syngeneic animals. When transfected with an episome-based vector encoding antisense IGF-I complementary DNA, these cells lost tumorigenicity. Subcutaneous injection of IGF-I antisense-transfected C6 cells into rats prevented formation of both subcutaneous tumors and brain tumors induced by nontransfected C6 cells. The antisense-transfected cells also caused regression of established brain… CONTINUE READING

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