Treatment Strategies Targeting Excess Hippocampal Activity Benefit Aged Rats with Cognitive Impairment

@article{Koh2010TreatmentST,
  title={Treatment Strategies Targeting Excess Hippocampal Activity Benefit Aged Rats with Cognitive Impairment},
  author={Ming Teng Koh and Rebecca P. Haberman and Stacey B Foti and Thomas J. McCown and Michela Gallagher},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={1016-1025}
}
Excess neural activity in the CA3 region of the hippocampus has been linked to memory impairment in aged rats. We tested whether interventions aimed at reducing this excess activity would improve memory performance. Aged (24 to 28 months old) male Long–Evans rats were characterized in a spatial memory task known to depend on the functional integrity of the hippocampus, such that aged rats with identified memory impairment were used in a series of experiments. Overexpression of the inhibitory… CONTINUE READING