Treatment-Emergent Sexual Dysfunction Related to Antidepressants: A Meta-Analysis

@article{Serretti2009TreatmentEmergentSD,
  title={Treatment-Emergent Sexual Dysfunction Related to Antidepressants: A Meta-Analysis},
  author={Alessandro Serretti and Alberto Chiesa},
  journal={Journal of Clinical Psychopharmacology},
  year={2009},
  volume={29},
  pages={259-266}
}
Background: Sexual dysfunction (SD) is an important underestimated adverse effect of antidepressant drugs. Patients, in fact, if not directly questioned, tend to scarcely report them. The aim of the present meta-analysis was to quantify SD caused by antidepressants on the basis of studies where sexual functioning was purposely investigated through direct inquiry and specific questionnaires. Methods: A literature search was conducted using MEDLINE, ISI Web of Knowledge, and references of… Expand
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Improved recognition and management of TESD may improve quality of life for MDD patients in usual clinical practice, with greater MDD effectiveness in favour of duloxetine. Expand
Sexual Dysfunction Related to Non-SSRI Second Generation Antidepressants: A Meta-Analysis
Objective: This systematic review is aimed to quantitatively summarise the prevalence of sexual dysfunction among non-SSRI second generation antidepressants namely agomelatine, bupropion, duloxetine,… Expand
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ANTIPSYCHOTICS AND SEXUAL DYSFUNCTION: EPIDEMIOLOGY, MECHANISMS AND MANAGEMENT
Objective: Growing attention has recently been given to the sexual dysfunction (SD) burden related to antipsychotics. The aims of the present work are 1) to review current evidence about SD related… Expand
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Although SD is an important adverse effect of antidepressant medication, patients tend to be reluctant to report them if not directly questioned, which suggests that consideration of the doctor-patient relationship is needed when deciding on an appropriate treatment plan. Expand
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TLDR
A concise, evidence-based schematic is presented to assist physicians in minimizing treatment-emergent sexual dysfunction (TESD) while treating depression. Expand
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TLDR
There is consistent evidence to suggest that antidepressant medication adversely affects one or more of the 3 phases of sexual response (desire, arousal and orgasm) and Clinicians must be aware of drug-induced sexual dysfunction. Expand
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Summary Objective Major depression is a chronic condition. Treatment with antidepressants is often stopped due to long-term side effects. Antidepressants are frequently associated with sexual… Expand
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TLDR
It is found that significant differences exist across different antipsychotics in terms of total SD, such as quetiapine, ziprasidone, perphenazine, and aripiprazole were associated with relatively low SD rates, whereas olanzapine and risperidone are associated with higher SD rates. Expand
Antidepressants and Sexual Dysfunction: Mechanisms and Clinical Implications
TLDR
A review of articles published within the last 10 years on sexual dysfunction and depression in adults, with an emphasis on the relationship of treatments for depression on SD, to aid physicians in the multidisciplinary approach to treating patients with SD and depression. Expand
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