Treatment-Emergent Sexual Dysfunction Related to Antidepressants: A Meta-Analysis

@article{Serretti2009TreatmentEmergentSD,
  title={Treatment-Emergent Sexual Dysfunction Related to Antidepressants: A Meta-Analysis},
  author={Alessandro Serretti and Alberto Chiesa},
  journal={Journal of Clinical Psychopharmacology},
  year={2009},
  volume={29},
  pages={259-266}
}
  • A. Serretti, A. Chiesa
  • Published 1 January 2009
  • Psychology, Medicine
  • Journal of Clinical Psychopharmacology
Background: Sexual dysfunction (SD) is an important underestimated adverse effect of antidepressant drugs. Patients, in fact, if not directly questioned, tend to scarcely report them. The aim of the present meta-analysis was to quantify SD caused by antidepressants on the basis of studies where sexual functioning was purposely investigated through direct inquiry and specific questionnaires. Methods: A literature search was conducted using MEDLINE, ISI Web of Knowledge, and references of… 
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431 Citations
Highly Influential Citations
20
Background Citations
149
Methods Citations
9
Results Citations
20

431 Citations

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There is consistent evidence to suggest that antidepressant medication adversely affects one or more of the 3 phases of sexual response (desire, arousal and orgasm) and Clinicians must be aware of drug-induced sexual dysfunction.
Pharmaceutical management of sexual dysfunction in men on antidepressant therapy
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This review covers the identification of symptoms of antidepressant-induced SD, prevalence of symptoms in association with commonly used antidepressants, and the main lines of management, with a focus on pharmacological strategies.
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A concise, evidence-based schematic is presented to assist physicians in minimizing treatment-emergent sexual dysfunction (TESD) while treating depression.
A meta-analysis of sexual dysfunction in psychiatric patients taking antipsychotics
TLDR
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Management of antidepressant-induced sexual dysfunction
  • N. Keks, J. Hope, C. Culhane
  • Psychology, Medicine
    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists
  • 2014
TLDR
The preponderance of evidence suggests that antidepressant s can be divided into high risk and low risk categories with regard to propensity for antidepressant-induced sexual dysfunction, although there is disagreement about mirtazapine and methodological issues militate against definitive findings.
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