Treatment-Emergent Sexual Dysfunction Related to Antidepressants: A Meta-Analysis

@article{Serretti2009TreatmentEmergentSD,
  title={Treatment-Emergent Sexual Dysfunction Related to Antidepressants: A Meta-Analysis},
  author={Alessandro Serretti and Alberto Chiesa},
  journal={Journal of Clinical Psychopharmacology},
  year={2009},
  volume={29},
  pages={259-266}
}
Background: Sexual dysfunction (SD) is an important underestimated adverse effect of antidepressant drugs. Patients, in fact, if not directly questioned, tend to scarcely report them. The aim of the present meta-analysis was to quantify SD caused by antidepressants on the basis of studies where sexual functioning was purposely investigated through direct inquiry and specific questionnaires. Methods: A literature search was conducted using MEDLINE, ISI Web of Knowledge, and references of… Expand
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There is consistent evidence to suggest that antidepressant medication adversely affects one or more of the 3 phases of sexual response (desire, arousal and orgasm) and Clinicians must be aware of drug-induced sexual dysfunction. Expand
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TLDR
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TLDR
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References

SHOWING 1-10 OF 82 REFERENCES
Sexual dysfunction during antidepressant treatment.
TLDR
The relatively high incidence of sexual dysfunction associated with antidepressant treatment in this systematic study emphasizes the importance of a detailed inquiry about sexual side effects as this interferes with treatment compliance. Expand
Effects of SSRIs on sexual function: a critical review.
TLDR
The effects of SSRIs on sexual functioning seem strongly dose-related and may vary among the group according to serotonin and dopamine reuptake mechanisms, induction of prolactin release, anticholinergic effects, inhibition of nitric oxide synthetase, and propensity for accumulation over time. Expand
Serotonin reuptake inhibitor-induced sexual dysfunction and its treatment: a large-scale retrospective study of 596 psychiatric outpatients.
TLDR
All three antidotes were found to be safe and relatively effective, although yohimbine was significantly more effective than amantadine or cyproheptadine in reversing SRI-induced sexual dysfunction. Expand
Incidence of sexual side effects in refractory depression during treatment with citalopram or paroxetine.
TLDR
Open-ended questions are an insufficient tool to estimate sexual dysfunction, and premarketing clinical trials should therefore include basic explicit assessments, and the failure to find a correlation between treatment duration and sexual dysfunction adds to the notion that sexual side effects due to SSRIs do not abate over time. Expand
Male Sexual Side Effects Associated with Antidepressants: A Descriptive Clinical Study of 32 Patients
  • Jeffrey H. Hsu, Winston W. Shen
  • Psychology, Medicine
  • International journal of psychiatry in medicine
  • 1995
TLDR
Male sexual side effects can occur randomly and involve any sexual phase randomly, and the treatment approaches are similar, regardless of the types of sexual dysfunction associated with antidepressants. Expand
Prevalence of sexual dysfunction among newer antidepressants.
TLDR
This is the first study to assess sexual dysfunction across the newer antidepressants using consistent methodology and a validated rating scale and overall, SSRIs and venlafaxine XR were associated with higher rates of sexual dysfunction than bupropion or nefazodone. Expand
Female Sexual Side Effects Associated with Selective Serotonin Reuptake Inhibitors: A Descriptive Clinical Study of 33 Patients
  • Winston W. Shen, Jeffrey H. Hsu
  • Psychology, Medicine
  • International journal of psychiatry in medicine
  • 1995
TLDR
It is suggested that SSRI-associated female sexual dysfunction occurs at a higher rate than previously thought, equal potentials in implicating female sexual side effects among three SSRIs, and the absence or the low incidence of female sexual adverse effects from bupropion. Expand
Fluoxetine-induced sexual dysfunction and an open trial of yohimbine.
  • F. M. Jacobsen
  • Psychology, Medicine
  • The Journal of clinical psychiatry
  • 1992
TLDR
It is suggested that fluoxetine-induced sexual dysfunction may include decreased sexual desire as well as decreased physical functioning and may occur more frequently than previously appreciated and fluoxete-inducedSexual dysfunction may be treatable with yohimbine. Expand
Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction.
TLDR
The incidence of sexual dysfunction with SSRIs and venlafaxine is high, ranging from 58% to 73%, as compared with serotonin-2 (5-HT2) blockers (nefazodone and mirtazapine), moclobemide, and amineptine. Expand
Changes in sexual functioning associated with duloxetine, escitalopram, and placebo in the treatment of patients with major depressive disorder.
TLDR
Regardless of treatment, patients who achieved remission of MDD showed improvement in global sexual functioning, whereas worsening was observed for patients who did not achieve remission (P < 0.001). Expand
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