Treating seizures in patients with brain tumors: Drug interactions between antiepileptic and chemotherapeutic agents.

@article{Vecht2003TreatingSI,
  title={Treating seizures in patients with brain tumors: Drug interactions between antiepileptic and chemotherapeutic agents.},
  author={Charles J. Vecht and G. Louis Wagner and Erik Bert Wilms},
  journal={Seminars in oncology},
  year={2003},
  volume={30 6 Suppl 19},
  pages={
          49-52
        }
}
Seizures are a common complication in patients with primary brain tumors or brain metastases that require treatment with antiepileptic drugs (AEDs). However, because many AEDs and chemotherapeutics share common metabolic pathways via the hepatic cytochrome P450 (CYP) isoenzymes, there is potential for drug interactions. Phenytoin, carbamazepine, and phenobarbital are potent enzyme-inducing AEDs (EIAEDs) that can cause a decrease in the serum concentration of chemotherapeutics, potentially… CONTINUE READING

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