Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog.

@article{Urdaneta2008TreatingPH,
  title={Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog.},
  author={Felipe Urdaneta and Emilio B. Lobato and Thomas Beaver and Jochen Daniel Muehlschlegel and David Se{\'a}n Kirby and Charles T. Klodell and Avner Sidi},
  journal={Perfusion},
  year={2008},
  volume={23 2},
  pages={117-25}
}
Procedures using cardiopulmonary bypass (CPB) and aortic cross-clamping are associated with a variable degree of ischemia/reperfusion of the lungs, leading to acute pulmonary hypertension (PHT). The purpose of this study was to compare the effects of the sildenafil analog (UK343-664), a phosphodiesterase type V(PDEV) inhibitor, with milrinone, a PDE type III inhibitor, in a porcine model of acute PHT following CPB. After the pigs were anesthetized, pressure-tipped catheters were placed in the… CONTINUE READING
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Retraction Statement The article ‘Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog

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