Treating childhood acute lymphoblastic leukemia without cranial irradiation.

  title={Treating childhood acute lymphoblastic leukemia without cranial irradiation.},
  author={Ching-Hon Pui and Dario Campana and Deqing Pei and William Paul Bowman and John T. Sandlund and Sue Creviston Kaste and Raul C. Ribeiro and Jeffrey E. Rubnitz and Susana C. Raimondi and Mihaela M Onciu and Elaine Coustan-Smith and Larry E. Kun and Sima Jeha and Cheng Cheng and Scott C. Howard and Vickey Simmons and Amy Bayles and Monika L. Metzger and James M. Boyett and Wing Leung and Rupert Handgretinger and James R. Downing and William E. Evans and Mary V. Relling},
  journal={The New England journal of medicine},
  volume={360 26},
BACKGROUND Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse. METHODS We conducted a clinical trial to test whether prophylactic cranial irradiation could be omitted from treatment in all children with newly diagnosed ALL. A total of 498 patients who could be evaluated were enrolled. Treatment intensity was based on presenting features and the level of minimal… CONTINUE READING
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