Treating asthma with anti-IgE or anti-IL5.

  title={Treating asthma with anti-IgE or anti-IL5.},
  author={Jan L{\"o}tvall and Teet Pullerits},
  journal={Current pharmaceutical design},
  volume={5 10},
In the last decades, several key mechanisms driving asthma pathophysiooogy have been discovered. These include the role of IgE in allergic disease, and the role of IL-5 in eosinophilic inflammation. In the last few years, tools to block each of these have been developed. At this time, early clinical studies with neutralizing antibodies against both IgE and IL-5 have been performed in asthma patients, with promising results, and larger studies are underway. The mechanisms of, and possible role… CONTINUE READING