Treadmill training ameliorates dopamine loss but not behavioral deficits in hemi-Parkinsonian rats

@article{Poulton2005TreadmillTA,
  title={Treadmill training ameliorates dopamine loss but not behavioral deficits in hemi-Parkinsonian rats},
  author={Nadine P. Poulton and Gillian D Muir},
  journal={Experimental Neurology},
  year={2005},
  volume={193},
  pages={181-197}
}
The purpose of this study was to investigate whether locomotor training could ameliorate neurochemical changes and behavioral deficits in the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease. It has been recently demonstrated that forelimb motor training, or brief treadmill training, can attenuate dopamine loss and some deficits in forelimb usage in this animal model. Nevertheless, it is not known whether locomotor training could result in an amelioration of locomotor deficits. Rats… CONTINUE READING
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