Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation.

@article{Liu2011TreadmillEP,
  title={Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation.},
  author={Hui-li Liu and Gang Zhao and Kui Cai and Hai-hua Zhao and Li-de Shi},
  journal={Behavioural brain research},
  year={2011},
  volume={218 2},
  pages={308-14}
}
Alzheimer's disease (AD) is a progressive neurodegenerative disease clinically characterized by learning and memory function deterioration. While it is well established that exercise can improve cognitive performance in AD, there have been few basic cellular and molecular mechanisms research performed to test the interaction between exercise and AD. In this study, we aimed at investigating whether treadmill exercise improves learning and memory function in APP/PS1 transgenic mouse model of… CONTINUE READING