Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.

@article{Rotzinger1998TrazodoneIM,
  title={Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.},
  author={Susan Rotzinger and J Fang and Glen B Baker},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1998},
  volume={26 6},
  pages={572-5}
}
The metabolism of the antidepressant drug trazodone to its active metabolite, m-chlorophenylpiperazine (mCPP), was studied in vitro using human liver microsomal preparations and cDNA-expressed human cytochrome P450 (P450) enzymes. The kinetics of mCPP formation from trazodone were determined, and three in vitro experiments were performed to identify the major P450 enzyme involved. Trazodone (100 microM) was incubated with 16 different human liver microsomal preparations characterized for… CONTINUE READING