Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.

@article{Kast2009TrazodoneGM,
  title={Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.},
  author={Richard E Kast},
  journal={The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry},
  year={2009},
  volume={10 4 Pt 2},
  pages={682-5}
}
Since deleterious effects of m-CPP, the primary catabolic metabolite of trazodone, were last reviewed 2 years ago, research data continue to accrue showing that clinically significant levels of m-CPP (a) are generated in patients using trazodone for sleep and (b) are present 24 h a day and (c) have potentially serious ill effects. This commentary argues that the documented potential for harm and multiple risks of m-CPP outweigh potential benefits of trazodone, given the development and… CONTINUE READING