Trazodone and valproate in patients discontinuing long-term benzodiazepine therapy: effects on withdrawal symptoms and taper outcome

@article{Rickels1999TrazodoneAV,
  title={Trazodone and valproate in patients discontinuing long-term benzodiazepine therapy: effects on withdrawal symptoms and taper outcome},
  author={K. Rickels and E. Schweizer and F. G. Garcia Espa{\~n}a and G. Case and N. Demartinis and D. Greenblatt},
  journal={Psychopharmacology},
  year={1999},
  volume={141},
  pages={1-5}
}
Abstract Recent uncontrolled research suggested that trazodone and sodium valproate may be helpful in benzodiazepine (BZ) discontinuation. We therefore undertook a double-blind study to assess whether trazodone and valproate, as compared to placebo, would attenuate withdrawal and facilitate discontinuation in BZ-dependent patients with a minimum of 1 year daily BZ use. Seventy-eight patients, taking a mean dose of 19 ± 17 mg/day of diazepam (or its equivalent), were stabilized for several weeks… Expand
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