Trazodone and valproate in patients discontinuing long-term benzodiazepine therapy: effects on withdrawal symptoms and taper outcome

  title={Trazodone and valproate in patients discontinuing long-term benzodiazepine therapy: effects on withdrawal symptoms and taper outcome},
  author={K. Rickels and E. Schweizer and F. G. Garcia Espa{\~n}a and G. Case and N. Demartinis and D. Greenblatt},
Abstract Recent uncontrolled research suggested that trazodone and sodium valproate may be helpful in benzodiazepine (BZ) discontinuation. We therefore undertook a double-blind study to assess whether trazodone and valproate, as compared to placebo, would attenuate withdrawal and facilitate discontinuation in BZ-dependent patients with a minimum of 1 year daily BZ use. Seventy-eight patients, taking a mean dose of 19 ± 17 mg/day of diazepam (or its equivalent), were stabilized for several weeks… Expand
62 Citations
Switching from long-term benzodiazepine therapy to pregabalin in patients with generalized anxiety disorder: a double-blind, placebo-controlled trial
  • 38
  • Highly Influenced
Pilot trial of gabapentin for the treatment of benzodiazepine abuse or dependence in methadone maintenance patients
  • 11
Assessment of Switching to Suvorexant versus the Use of Add-on Suvorexant in Combination with Benzodiazepine Receptor Agonists in Insomnia Patients: A Retrospective Study
  • Masakazu Hatano, Hiroyuki Kamei, +4 authors N. Iwata
  • Medicine
  • Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2018
  • 4
  • PDF


Carbamazepine treatment in patients discontinuing long-term benzodiazepine therapy. Effects on withdrawal severity and outcome.
  • 112
Long-term therapeutic use of benzodiazepines. I. Effects of abrupt discontinuation.
  • 260
A Comparison of Buspirone and Placebo in Relieving Benzodiazepine Withdrawal Symptoms
  • 65
Antidepressants for the treatment of generalized anxiety disorder. A placebo-controlled comparison of imipramine, trazodone, and diazepam.
  • 390
Ineffectiveness of clonidine in the treatment of the benzodiazepine withdrawal syndrome: report of three cases.
  • 34
Failure of buspirone to manage benzodiazepine withdrawal.
  • 65
Lorazepam‐Valproate Interaction: Studies in Normal Subjects and Isolated Perfused Rat Liver
  • 42
Valproate and Carbamazepine in the Treatment of Panic and Posttraumatic Stress Disorders, Withdrawal States, and Behavioral Dyscontrol Syndromes
  • 123
Antiepileptic Drug Mechanisms of Action
  • 391
  • PDF
Effect of Valproate on Human Cerebral Glucose Metabolism
  • 96