Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPγS binding

@article{Odagaki2005TrazodoneAI,
  title={Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTP$\gamma$S binding},
  author={Yuji Odagaki and Ryoichi Toyoshima and Toshio Yamauchi},
  journal={Journal of Psychopharmacology},
  year={2005},
  volume={19},
  pages={235 - 241}
}
Trazodone is an effective antidepressant drug with a broad therapeutic spectrum, including anxiolytic efficacy. Although trazodone is usually referred to as a serotonin (5-HT) reuptake inhibitor, this pharmacological effect appears to be too weak to fully account for its clinical effectiveness. The present study aimed to elucidate the agonist properties of trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP), at 5-HT1A receptors by means of the guanosine-5′-O-(3-[35S]thio… 
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