Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis.

@article{Moore2005TraversingTC,
  title={Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis.},
  author={Jason H. Moore and Scott M. Williams},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2005},
  volume={27 6},
  pages={
          637-46
        }
}
Epistasis plays an important role in the genetic architecture of common human diseases and can be viewed from two perspectives, biological and statistical, each derived from and leading to different assumptions and research strategies. Biological epistasis is the result of physical interactions among biomolecules within gene regulatory networks and biochemical pathways in an individual such that the effect of a gene on a phenotype is dependent on one or more other genes. In contrast… 
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