Travelling waves in somitogenesis: collective cellular properties emerge from time-delayed juxtacrine oscillation coupling

@inproceedings{Tomka2018TravellingWI,
  title={Travelling waves in somitogenesis: collective cellular properties emerge from time-delayed juxtacrine oscillation coupling},
  author={Tomas Tomka and Dagmar Iber and Marcelo Boareto},
  year={2018}
}
The sculpturing of the vertebrate body plan into segments begins with the sequential formation of somites in the presomitic mesoderm (PSM). The rhythmicity of this process is controlled by travelling waves of gene expression. These kinetic waves emerge from coupled cellular oscillators and sweep across the PSM. In zebrafish, the oscillations are driven by autorepression of her genes and are synchronized via Notch signalling. Mathematical modelling has played an important role in explaining how… CONTINUE READING