Travelers' diarrhea: antimicrobial therapy and chemoprevention

@article{Dupont2005TravelersDA,
  title={Travelers' diarrhea: antimicrobial therapy and chemoprevention},
  author={Herbert Dupont},
  journal={Nature Clinical Practice Gastroenterology \&Hepatology},
  year={2005},
  volume={2},
  pages={191-198}
}
  • H. Dupont
  • Published 1 April 2005
  • Medicine
  • Nature Clinical Practice Gastroenterology &Hepatology
The use of preventive measures and self-treatment for travelers' diarrhea is routine in regions where the occurrence of diarrhea is predictably high. [] Key Method All people who travel to high-risk areas should take curative antimicrobial agents with them for self-treatment of illness: rifaximin 200 mg three times a day for 3 days, or an absorbable agent such as a fluoroquinolone or azithromycin taken in a single dose initially, with the need for a second or third dose determined by clinical response…
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35 Citations
Background Citations
7
Results Citations
1

35 Citations

Treatment of Traveler’s Diarrhea
TLDR
Antibiotics, which are the only causative treatment option, shorten the duration of symptoms and eliminate the causative bacteria, and are therefore recommended for treatment of moderate and severe traveler’s diarrhea.
Current and future developments in travelers’ diarrhea therapy
TLDR
Rifaximin with an excellent safety profile and limited potential to induce coliform resistance, prevents most of the diarrhea that would otherwise occur and should be given to the routine use of chemoprophylaxis for travelers to high-risk countries.
Travelers' preferences for the treatment and prevention of acute diarrhea.
TLDR
The UK and German travelers were more cognizant of TD risk than US and Canadian travelers and preferred treatment or prophylaxis with the nonabsorbed antibiotic over the systemically absorbed antibiotic or the antidiarrheal agent.
Prevention of travelers' diarrhea with rifaximin in US travelers to Mexico.
TLDR
Prophylactic treatment with rifaximin 600 mg/d for 14 days safely and effectively reduced the risk of developing TD in US travelers to Mexico.
Is There a Role for Bismuth in Diarrhea Management?
TLDR
The antisecretory, anti-inflammatory, and antibacterial properties of bismuth make it a suitable therapy for symptomatic treatment of diarrhea, and the limited range of adverse side effects makes it an appealing option for patients with numerous comorbidities.
Unexplained benefits of antibiotics in childhood: empiricism in need of enlightenment.
TLDR
By adding azithromycin to chloroquine to treat childhood malaria, the incidences of subsequent respiratory and gastrointestinal infections are lowered, and times to next pulmonary and diarrheal illness are prolonged, Gilliams et al report.
What's new in enteric infectious diseases at home and abroad
  • H. Dupont
  • Medicine
    Current opinion in infectious diseases
  • 2005
TLDR
The nonabsorbed rifamycin drug, rifaximin, appears to be ideally suited to become the important new drug in prevention and treatment of travelers’ diarrhea.
Epidemiology, Etiology and Pathophysiology of Traveler’s Diarrhea
TLDR
Several personal and environmental risk factors are at the basis of TD acquisition and are discussed in this paper and some of them are still poorly understood.
Bacterial flora in digestive disease : focus on rifaximin
Foreword: Vilardell, F. Preface: Scarpignato, C. Lanas, A. Enteric Flora in Health and Disease: Guarner, F. Experimental and Clinical Pharmacology of Rifaximin, a Gastrointestinal Selective…
Treatment of Diarrhoea in Rural African Communities: An Overview of Measures to Maximise the Medicinal Potentials of Indigenous Plants
TLDR
This review appraises the current strategies used in the treatment of diarrhoea according to the Western orthodox and indigenous African health-care systems and points out major areas that could be targeted by health-promotion efforts as a means to improve management and alleviate suffering associated with diarrhea in rural areas of the developing world.
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References

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