Traumatic brain injury: cause or risk of Alzheimer’s disease? A review of experimental studies

@article{Szczygielski2005TraumaticBI,
  title={Traumatic brain injury: cause or risk of Alzheimer’s disease? A review of experimental studies},
  author={Jacek Szczygielski and Angelika E. M. Mautes and Wolf-Ingo Steudel and Peter G Falkai and Thomas A. Bayer and Oliver Wirths},
  journal={Journal of Neural Transmission},
  year={2005},
  volume={112},
  pages={1547-1564}
}
Summary.Traumatic Brain Injury is the leading cause of death and disability among young individuals in our society. Moreover, according to some epidemiological studies, head trauma is one of the most potent environmental risk factors for subsequent development of Alzheimer’s disease. Interestingly, pathological features that are present also in Alzheimer’s disease (in particular deposition of beta-amyloid protein) were observed in traumatised brains already a few hours after the initial insult… 

Neuropathology of Traumatic Brain Injury and Its Role in the Development of Alzheimer’s Disease

Despite recent progress more studies are required to further understanding of the basic mechanisms and pathophysiology of TBI, elucidate the precise association between TBI and neurodegenerative disease, and to identify treatments and therapies that can mitigate long-term consequences.

Traumatic brain injury: A risk factor for Alzheimer's disease

Brain injury, neuroinflammation and Alzheimer's disease

A thorough, mechanistic understanding of the precise relationship between TBI and AD is of utmost importance in order to illuminate new therapeutic targets and accurate modeling of pathological hallmarks in animal systems.

The Response of Cerebral Cortex to Haemorrhagic Damage: Experimental Evidence from a Penetrating Injury Model

The findings support the possibility that haemorrhagic damage to the brain can lead to plaque-like pathology in humans diagnosed with Alzheimer’s disease.

Traumatic Brain Injury as a Risk Factor for Dementia and Alzheimer's Disease: Critical Review of Study Methodologies.

This critical review identified several key areas of methodological weakness and rigour, and should be used as a guideline for improving future research.

The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease

Experimental studies examining the relationship between TBI and development of AD-like pathology with an emphasis on the acute and chronic microglial and macrophage response following injury suggest that the brain’s immune response to injury is a key mediator in recovery, and if compromised by previous, coincident, or subsequent immune stressors, post-injury pathology and behavioral recovery will be altered.

Experimental models of repetitive brain injuries.

  • J. Weber
  • Biology
    Progress in brain research
  • 2007

What affects the risk of developing Alzheimer's disease? Overview of risk factors

The factors presented are very numerous, which indicates the fact that there are many disorders that may influence the development of Alzheimer's disease to a greater or lesser degree, however the most important are the genetic factors and antioxidant deficiencies causing oxidative stress.

Risk and protective factors for sporadic Alzheimer's disease.

Empirical investigations show that midlife hypertension, cardiovascular diseases, hypercholesterolemia, diabetes, obesity, inflammation, and viral infections can significantly contribute to the development and progression of AD, whereas active engagement in social, mental and physical activities may delay the onset of the disease.
...

References

SHOWING 1-10 OF 146 REFERENCES

Traumatic Brain Injury as a Risk Factor for Alzheimer's Disease: A Review

The literature reviewed provides sufficient support and empirical vindication to give credence to the proposed association between these two neuropsychological entities at the statistical, theoretical, and biological level.

Traumatic brain injury as a risk factor for Alzheimer's disease: a review.

The literature reviewed provides sufficient support and empirical vindication to give credence to the proposed association between these two neuropsychological entities at the statistical, theoretical, and biological level.

Traumatic brain injury as a risk factor for Alzheimer's disease.

  • K. Jellinger
  • Biology, Psychology
    Journal of neurology, neurosurgery, and psychiatry
  • 2004
Findings support in males only an association between a history of previous head injury and the risk of developing AD, but the study could not review the relation betweenHead injury and ApoE gene status as risk factors for Alzheimer’s disease.

Altered β-APP Metabolism After Head Injury and its Relationship to the Aetiology of Alzheimer’s Disease

There is increasing evidence of a link between head injury and the subsequent onset of Alzheimer’s disease and there is an increased expression of β-APP particularly in the pre-α cells of the entorhinal cortex and in areas of axonal damage.

Altered beta-APP metabolism after head injury and its relationship to the aetiology of Alzheimer's disease.

Clinopathological studies have shown that A beta deposition is most likely, but not exclusively, to occur, the older the patient at the time of injury, and if the injury is the result of a fall.

Head injury doubles the risk of Alzheimer's disease

Young adults who experience a moderate or severe head injury have more than double the risk of developing Alzheimer's disease and other forms of dementia later in life, according to a new study. Dr

Post–traumatic Alzheimer's disease: preponderance of a single plaque type

This work has shown that the brains of boxers with dementia pugilistica (punch drunk syndrome) contain large numbers of ‘diffuse’ p–protein immunoreactive plaques, which might be associated with trauma induced Alzheimer–like degeneration.

Tau immunohistochemistry in acute brain injury

It is hypothesized that tau‐immunoreactive tangles may be present in the brains of patients who died after a single acute blunt head injury and Subtle alterations in tau immunoreactivity were present in some head injury cases but not controls.

Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury

Neuronal cytoskeletal changes are an early consequence of repetitive head injury

It appears that repetitive head injury in young adults is initially associated with neocortical NFT formation in the absence of Aβ deposition, and the distribution of the tau pathology suggests that the pathogenesis of cytoskeletal abnormalities may involve damage to blood vessels or perivascular elements.
...