Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice.

@article{Saatman2003TraumaticAI,
  title={Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice.},
  author={Kathryn Saatman and Babak Abai and Ashley Grosvenor and Christian K. Vorwerk and Douglas Harold Smith and David F. Meaney},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2003},
  volume={23 1},
  pages={
          34-42
        }
}
Traumatic axonal injury (TAI) is one of the most important pathologies associated with closed head injury, and contributes to ensuing morbidity. The authors evaluated the potential role of calpains in TAI using a new model of optic nerve stretch injury in mice. Male C57BL/6 mice were anesthetized, surgically prepared, and subjected to a 2.0-mm optic nerve stretch injury (n = 34) or sham injury (n = 18). At various intervals up to 2 weeks after injury, optic nerves were examined for… CONTINUE READING

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